George G Schweitzer
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Explore the profile of George G Schweitzer including associated specialties, affiliations and a list of published articles.
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31
Citations
836
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Recent Articles
1.
Schweitzer G, Ditzenberger G, Hughey C, Finck B, Martino M, Pacak C, et al.
PLoS One
. 2023 Aug;
18(8):e0290832.
PMID: 37651450
Methods: Male TAFAZZIN shRNA transgenic (TG) and wild-type (WT) mice completed exhaustive treadmill running protocols to test exercise tolerance. Mice underwent 2H- and 13C-stable isotope infusions at rest and during...
2.
Beals J, Kayser B, Smith G, Schweitzer G, Kirbach K, Kearney M, et al.
Nat Metab
. 2023 Jun;
5(7):1221-1235.
PMID: 37365374
The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. Here, we show that whole-body (primarily muscle) insulin sensitivity...
3.
Schweitzer G, Beckner D, Smith G, Klein S
J Endocr Soc
. 2023 May;
7(6):bvad048.
PMID: 37153109
Context: The Pritikin Program, which provides intensive lifestyle therapy, has been shown to improve cardiometabolic outcomes when provided as a residential program. Objective: The purpose of the present study was...
4.
Farabi S, Smith G, Schweitzer G, Stein R, Klein S
Int J Obes (Lond)
. 2022 Jul;
46(10):1778-1785.
PMID: 35817849
Background And Objectives: Although obesity is typically associated with metabolic co-morbidities, some people with obesity do not develop metabolic abnormalities. We evaluated whether modifiable lifestyle factors (i.e., physical activity, dietary...
5.
Chambers K, Cooper M, Swearingen A, Brookheart R, Schweitzer G, Weinheimer C, et al.
JCI Insight
. 2021 May;
6(9).
PMID: 33986192
Lipin 1 is a bifunctional protein that is a transcriptional regulator and has phosphatidic acid (PA) phosphohydrolase activity, which dephosphorylates PA to generate diacylglycerol. Human lipin 1 mutations lead to...
6.
Beals J, Smith G, Shankaran M, Fuchs A, Schweitzer G, Yoshino J, et al.
Hepatology
. 2021 Mar;
74(3):1287-1299.
PMID: 33743554
Background And Aims: It is proposed that impaired expansion of subcutaneous adipose tissue (SAT) and an increase in adipose tissue (AT) fibrosis causes ectopic lipid accumulation, insulin resistance (IR), and...
7.
Barenie M, Domenick J, Bennett J, Schweitzer G, Shetty P, Weiss E
Int J Exerc Sci
. 2021 Jan;
13(7):1770-1782.
PMID: 33414887
The purpose of this study was to evaluate the hypothesis that a novel high-repetition, low-resistance back squat training protocol, designed to stimulate high-intensity interval training, improves 5-km run performance. Fifteen...
8.
Smith G, Shankaran M, Yoshino M, Schweitzer G, Chondronikola M, Beals J, et al.
J Clin Invest
. 2019 Dec;
130(3):1453-1460.
PMID: 31805015
BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis...
9.
Schweitzer G, Gan C, Bucelli R, Wegner D, Schmidt R, Shinawi M, et al.
Mol Genet Genomic Med
. 2019 May;
7(7):e00733.
PMID: 31070020
Background: Site-1 Protease (S1P) is a Golgi-resident protein required for the activation of regulatory proteins that drive key cellular functions, including, the unfolded protein response (UPR) and lipid and cholesterol...
10.
Cade W, Bohnert K, Peterson L, Patterson B, Bittel A, Okunade A, et al.
J Inherit Metab Dis
. 2019 Mar;
42(3):480-493.
PMID: 30924938
Barth syndrome (BTHS) is a rare X-linked condition resulting in abnormal mitochondria, cardioskeletal myopathy, and growth delay; however, the effects of BTHS on substrate metabolism regulation and their relationships with...