George Eng
Overview
Explore the profile of George Eng including associated specialties, affiliations and a list of published articles.
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Articles
61
Citations
2080
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Recent Articles
1.
Khademhosseini A, Suh K, Yang J, Eng G, Yeh J, Levenberg S, et al.
Biomaterials
. 2025 Feb;
318:123171.
PMID: 39934041
No abstract available.
2.
Yilmaz O, Arora K, Lee S, Hosseini S, Chen F, Padmanabha N, et al.
J Clin Pathol
. 2025 Jan;
PMID: 39788729
Aims: WNT signalling pathway dysregulation is often a critical early component in colorectal neoplasia, particularly the chromosomal instability pathway. Using two WNT reporters, and , we sought to assess whether...
3.
Chen J, Merrick K, Kong Y, Izrael-Tomasevic A, Eng G, Handly E, et al.
Cell Rep Med
. 2024 Oct;
5(10):101778.
PMID: 39378883
5-fluorouracil (5-FU), a major anti-cancer therapeutic, is believed to function primarily by inhibiting thymidylate synthase, depleting deoxythymidine triphosphate (dTTP), and causing DNA damage. Here, we show that clinical combinations of...
4.
Goto N, Westcott P, Goto S, Imada S, Taylor M, Eng G, et al.
Nature
. 2024 Feb;
627(8004):636-645.
PMID: 38418875
A hallmark of cancer is the avoidance of immune destruction. This process has been primarily investigated in locally advanced or metastatic cancer; however, much less is known about how pre-malignant...
5.
Taylor M, Wu C, Fridy P, Zhang S, Senussi Y, Wolters J, et al.
Cancer Discov
. 2023 Sep;
13(12):2532-2547.
PMID: 37698949
Significance: The LINE-1 ORF1p transposon protein is pervasively expressed in many cancers and is a highly specific biomarker of multiple common, lethal carcinomas and their high-risk precursors in tissue and...
6.
Lee M, Eng G, Handte-Reinecker A, Deshpande V, Yilmaz O, Gala M
Gastroenterology
. 2023 Jul;
165(5):1276-1279.e7.
PMID: 37507074
No abstract available.
7.
Chen J, Merrick K, Kong Y, Izrael-Tomasevic A, Eng G, Handly E, et al.
bioRxiv
. 2023 May;
PMID: 37162991
5-fluorouracil (5-FU) is a successful and broadly used anti-cancer therapeutic. A major mechanism of action of 5-FU is thought to be through thymidylate synthase (TYMS) inhibition resulting in dTTP depletion...
8.
Taylor M, Connie W, Fridy P, Zhang S, Senussi Y, Wolters J, et al.
bioRxiv
. 2023 Feb;
PMID: 36747644
Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring treatment response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity for...
9.
Hwang W, Jagadeesh K, Guo J, Hoffman H, Yadollahpour P, Reeves J, et al.
Nat Genet
. 2022 Jul;
54(8):1178-1191.
PMID: 35902743
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet inform clinical management or therapeutic development. Here, we...
10.
Hwabejire J, Kaafarani H, Mashbari H, Misdraji J, Fagenholz P, Gartland R, et al.
Am Surg
. 2021 Nov;
87(12):1893-1900.
PMID: 34772281
Background: COVID-19 is a deadly multisystemic disease, and bowel ischemia, the most consequential gastrointestinal manifestation, remains poorly described. Our goal is to describe our institution's surgical experience with management of...