George D Demetri
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Explore the profile of George D Demetri including associated specialties, affiliations and a list of published articles.
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Articles
229
Citations
21076
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Recent Articles
21.
Stacchiotti S, Frezza A, Blay J, Baldini E, Bonvalot S, Bovee J, et al.
Cancer
. 2021 Apr;
127(16):2934-2942.
PMID: 33910263
Background: Among sarcomas, which are rare cancers, many types are exceedingly rare; however, a definition of ultra-rare cancers has not been established. The problem of ultra-rare sarcomas is particularly relevant...
22.
23.
Demetri G, Stacchiotti S
Oncology
. 2021 Apr;
99 Suppl 1:3-7.
PMID: 33853076
Real-world data are defined as data relating to any aspect of a patient's health status collected in the context of routine health surveillance and medical care delivery. Sources range from...
24.
Demetri G, Luke J, Hollebecque A, Powderly 2nd J, Spira A, Subbiah V, et al.
Clin Cancer Res
. 2021 Apr;
27(13):3556-3566.
PMID: 33820780
Purpose: Leucine-rich repeat containing 15 (LRRC15) is expressed on stromal fibroblasts in the tumor microenvironment of multiple solid tumor types and may represent an interesting target for therapy, particularly in...
25.
Iida K, Abdelhamid Ahmed A, Nagatsuma A, Shibutani T, Yasuda S, Kitamura M, et al.
Cancer Discov
. 2021 Feb;
11(6):1508-1523.
PMID: 33579785
Currently, the only approved treatments for gastrointestinal stromal tumor (GIST) are tyrosine kinase inhibitors (TKI), which eventually lead to the development of secondary resistance mutations in KIT or PDGFRA and...
26.
Hemming M, Coy S, Lin J, Andersen J, Przybyl J, Mazzola E, et al.
Clin Cancer Res
. 2021 Jan;
27(6):1706-1719.
PMID: 33451979
Purpose: Gastrointestinal stromal tumor (GIST) arises from interstitial cells of Cajal (ICC) or their precursors, which are present throughout the gastrointestinal tract. Although gastric GIST is commonly indolent and small...
27.
Singh H, Li Y, Spurr L, Shinagare A, Abhyankar R, Reilly E, et al.
Clin Cancer Res
. 2021 Jan;
27(6):1695-1705.
PMID: 33414136
Purpose: Receptor tyrosine kinase fusions in colorectal cancers are rare, but potentially therapeutically relevant. We describe clinical, molecular, and pathologic attributes of RTK fusion-associated colorectal cancer. Experimental Design: We identified...
28.
Gounder M, Merriam P, Ratan R, Patel S, Chugh R, Villalobos V, et al.
Cancer
. 2020 Dec;
127(8):1311-1317.
PMID: 33296083
Background: Limited data are available on the real-world effectiveness and safety of systemic therapies for advanced (surgically unresectable and/or metastatic) epithelioid sarcoma (ES). Methods: A retrospective medical records review was...
29.
Kluetz P, Keegan P, Demetri G, Thornton K, Sul J, Kim J, et al.
Clin Cancer Res
. 2020 Dec;
27(4):916-921.
PMID: 33257426
The FDA conducts independent reviews of scientific data obtained with investigational drug products to ensure that they are safe and effective. As a result of this process, FDA-approved product labeling...
30.
Gounder M, Schoffski P, Jones R, Agulnik M, Cote G, Villalobos V, et al.
Lancet Oncol
. 2020 Oct;
21(11):1423-1432.
PMID: 33035459
Background: Epithelioid sarcoma is a rare and aggressive soft-tissue sarcoma subtype. Over 90% of tumours have lost INI1 expression, leading to oncogenic dependence on the transcriptional repressor EZH2. In this...