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George A Gutman

Explore the profile of George A Gutman including associated specialties, affiliations and a list of published articles. Areas
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Articles 15
Citations 1799
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Recent Articles
1.
Chhabra S, Chang S, Nguyen H, Huq R, Tanner M, Londono L, et al.
FASEB J . 2014 Jun; 28(9):3952-64. PMID: 24891519
The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for immunomodulation in autoimmune diseases. ShK-186, a selective inhibitor of Kv1.3 channels, ameliorates autoimmune diseases in rodent...
2.
Harmar A, Hills R, Rosser E, Jones M, Buneman O, Dunbar D, et al.
Nucleic Acids Res . 2008 Oct; 37(Database issue):D680-5. PMID: 18948278
The IUPHAR database (IUPHAR-DB) integrates peer-reviewed pharmacological, chemical, genetic, functional and anatomical information on the 354 nonsensory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-like ion...
3.
Jang G, Tanaka B, Gutman G, Goldin A, Semler B
Gene . 2007 Dec; 408(1-2):133-45. PMID: 18077107
We investigated the role of the 3' non-coding region of a mouse voltage-gated potassium channel mRNA (mKv1.4 mRNA) in post-transcriptional regulation of gene expression. In contrast to an earlier report...
4.
Beeton C, Wulff H, Standifer N, Azam P, Mullen K, Pennington M, et al.
Proc Natl Acad Sci U S A . 2006 Nov; 103(46):17414-9. PMID: 17088564
Autoreactive memory T lymphocytes are implicated in the pathogenesis of autoimmune diseases. Here we demonstrate that disease-associated autoreactive T cells from patients with type-1 diabetes mellitus or rheumatoid arthritis (RA)...
5.
Cahalan M, Gutman G
Nat Immunol . 2006 Mar; 7(4):329-32. PMID: 16550194
This series of reviews examines the effect of differing tissue environments on the activity and functional capacity of cells in the immune system. From their origins as hematopoietic stem cells,...
6.
Gutman G, Chandy K, Grissmer S, Lazdunski M, McKinnon D, Pardo L, et al.
Pharmacol Rev . 2005 Dec; 57(4):473-508. PMID: 16382104
No abstract available.
7.
Wei A, Gutman G, Aldrich R, Chandy K, Grissmer S, Wulff H
Pharmacol Rev . 2005 Dec; 57(4):463-72. PMID: 16382103
No abstract available.
8.
Yu F, Yarov-Yarovoy V, Gutman G, Catterall W
Pharmacol Rev . 2005 Dec; 57(4):387-95. PMID: 16382097
No abstract available.
9.
Beeton C, Pennington M, Wulff H, Singh S, Nugent D, Crossley G, et al.
Mol Pharmacol . 2005 Jan; 67(4):1369-81. PMID: 15665253
The voltage-gated Kv1.3 K(+) channel is a novel target for immunomodulation of autoreactive effector memory T (T(EM)) cells that play a major role in the pathogenesis of autoimmune diseases. We...
10.
Jang G, Leong L, Hoang L, Wang P, Gutman G, Semler B
J Biol Chem . 2004 Sep; 279(46):47419-30. PMID: 15339906
The approximately 1.2-kb 5'-noncoding region (5'-NCR) of mRNA species encoding mouse Kv1.4, a member of the Shaker-related subfamily of voltage-gated potassium channels, was shown to mediate internal ribosome entry in...