George A Brooks
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Explore the profile of George A Brooks including associated specialties, affiliations and a list of published articles.
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Articles
106
Citations
4675
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Recent Articles
1.
Leija R, Arevalo J, Xing D, Vazquez-Medina J, Brooks G
Am J Physiol Endocrinol Metab
. 2024 Dec;
328(1):E126-E136.
PMID: 39714986
The lactate shuttle concept has revolutionized our understanding and study of metabolism in physiology, biochemistry, intermediary metabolism, nutrition, and medicine. Seminal findings of the mitochondrial lactate oxidation complex (mLOC) elucidated...
2.
Osmond A, Leija R, Arevalo J, Curl C, Duong J, Huie M, et al.
J Appl Physiol (1985)
. 2024 Sep;
137(5):1200-1219.
PMID: 39236144
Plasma glycerol and free fatty acid concentrations decrease following oral glucose consumption, but changes in the rate of lipolysis during an oral glucose tolerance test (OGTT) have not been documented...
3.
Arevalo J, Leija R, Osmond A, Curl C, Duong J, Huie M, et al.
Am J Physiol Endocrinol Metab
. 2024 Aug;
327(4):E430-E440.
PMID: 39110417
Lactate, a product of glycolysis, is formed under aerobic conditions. Extensive work has shown lactate flux in young and exercising humans; however, the effect of age is not known. We...
4.
Duong J, Leija R, Osmond A, Arevalo J, Brooks G
J Appl Physiol (1985)
. 2024 Aug;
137(4):857-863.
PMID: 39088644
Muscular efficiency during exercise has been used to interrogate aspects of human muscle energetics, including mitochondrial coupling and biomechanical efficiencies. Typically, assessments of muscular efficiency have involved graded exercises. Results...
5.
Curl C, Leija R, Arevalo J, Osmond A, Duong J, Huie M, et al.
Am J Physiol Endocrinol Metab
. 2024 Jun;
327(2):E217-E228.
PMID: 38895979
Our purpose was to determine how age affects metabolic flexibility and underlying glucose kinetics in healthy young and older adults. Therefore, glucose and lactate tracers along with pulmonary gas exchange...
6.
Brooks G, Gaesser G, Poole D
J Physiol
. 2024 May;
602(14):3233-3235.
PMID: 38775160
No abstract available.
7.
Leija R, Curl C, Arevalo J, Osmond A, Duong J, Huie M, et al.
Nat Metab
. 2024 Feb;
6(4):670-677.
PMID: 38388706
Dietary glucose in excess is stored in the liver in the form of glycogen. As opposed to direct conversion of glucose into glycogen, the hypothesis of the postprandial lactate shuttle...
8.
Curl C, Leija R, Arevalo J, Osmond A, Duong J, Kaufer D, et al.
Int J Mol Sci
. 2023 Sep;
24(17).
PMID: 37686002
Brain injuries (BI) are highly disruptive, often having long lasting effects. Inadequate standard of care (SOC) energy support in the hospital leads to dietary energy deficiencies in BI patients. However,...
9.
Brooks G
Nutrients
. 2023 Jul;
15(9).
PMID: 37432330
The discovery of the lactate shuttle (LS) mechanism may have two opposite perceptions, It may mean very little, because the body normally and inexorably uses the LS mechanism. On the...
10.
San-Millan I, Martinez J, Pickard S, Yu H, Hirsch F, Rivard C, et al.
bioRxiv
. 2023 Mar;
PMID: 36993762
The Warburg Effect is characterized by accelerated glycolytic metabolism and lactate production and under fully aerobic conditions is a hallmark of cancer cells. Recently, we have demonstrated the role of...