Georg Kuenze
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Explore the profile of Georg Kuenze including associated specialties, affiliations and a list of published articles.
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24
Citations
617
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Recent Articles
1.
Geist C, Useini A, Kazimir A, Kuempfel R, Meiler J, Lamers C, et al.
bioRxiv
. 2024 Dec;
PMID: 39651167
Computational protein design is becoming increasingly helpful in the development of new protein therapeutics with enhanced efficacy, specificity, and minimal side effects, for precise modulation of biological pathways. In vascular...
2.
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet M, Ambreen S, et al.
Nat Commun
. 2024 Sep;
15(1):7963.
PMID: 39261453
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR). While...
3.
Manoharan J, Rana R, Kuenze G, Gupta D, Elwakiel A, Ambreen S, et al.
Immunity
. 2023 Dec;
57(1):68-85.e11.
PMID: 38141610
Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation and coagulation-dependent inflammation. TF also exerts protective effects through unknown mechanisms. Here, we showed that TF...
4.
Marlow B, Kuenze G, Meiler J, Leman J
PLoS Comput Biol
. 2023 Mar;
19(3):e1010947.
PMID: 36972273
Lipid molecules such as cholesterol interact with the surface of integral membrane proteins (IMP) in a mode different from drug-like molecules in a protein binding pocket. These differences are due...
5.
Mukherjee S, Cassini T, Hu N, Yang T, Li B, Shen W, et al.
HGG Adv
. 2022 Aug;
3(4):100131.
PMID: 36035247
Whole-exome sequencing (WES) in the clinic has identified several rare monogenic developmental and epileptic encephalopathies (DEE) caused by ion channel variants. However, WES often fails to provide actionable insight for...
6.
Phul S, Kuenze G, Vanoye C, Sanders C, George Jr A, Meiler J
PLoS Comput Biol
. 2022 Apr;
18(4):e1010038.
PMID: 35442947
Recent advances in experimental and computational protein structure determination have provided access to high-quality structures for most human proteins and mutants thereof. However, linking changes in structure in protein mutants...
7.
Leman J, Lyskov S, Lewis S, Adolf-Bryfogle J, Alford R, Barlow K, et al.
Nat Commun
. 2021 Nov;
12(1):6947.
PMID: 34845212
Each year vast international resources are wasted on irreproducible research. The scientific community has been slow to adopt standard software engineering practices, despite the increases in high-dimensional data, complexities of...
8.
Chen Z, Kuenze G, Meiler J, Canessa C
J Gen Physiol
. 2021 Apr;
153(5).
PMID: 33851970
Acid-sensing ion channels (ASICs) respond to changes in pH in the central and peripheral nervous systems and participate in synaptic plasticity and pain perception. Understanding the proton-mediated gating mechanism remains...
9.
Schoeder C, Schmitz S, Adolf-Bryfogle J, Sevy A, Finn J, Sauer M, et al.
Biochemistry
. 2021 Mar;
60(11):825-846.
PMID: 33705117
Structure-based antibody and antigen design has advanced greatly in recent years, due not only to the increasing availability of experimentally determined structures but also to improved computational methods for both...
10.
Marlow B, Kuenze G, Li B, Sanders C, Meiler J
Biophys J
. 2021 Feb;
120(9):1592-1604.
PMID: 33640379
Cholesterol is an integral component of mammalian membranes. It has been shown to modulate membrane fluidity and dynamics and alter integral membrane protein function. However, understanding the molecular mechanisms of...