Geoffrey D Shimberg
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Explore the profile of Geoffrey D Shimberg including associated specialties, affiliations and a list of published articles.
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9
Citations
100
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Recent Articles
1.
Spangler A, Shimberg G, Mantus G, Malek R, Cominsky L, Tsybovsky Y, et al.
Immunity
. 2025 Mar;
58(3):728-744.e9.
PMID: 40023164
Pre-existing immunity impacts vaccine responses to influenza, but directly connecting influenza infections early in life with immune responses decades later is difficult. However, H2N2 stopped circulating in the human population...
2.
Mantus G, Chopde A, Gorman J, Cominsky L, Ourahmane A, Creanga A, et al.
Sci Transl Med
. 2025 Jan;
17(779):eadr8373.
PMID: 39742506
The conserved influenza hemagglutinin stem, which is a target of cross-neutralizing antibodies, is now used in vaccine strategies focused on protecting against influenza pandemics. Antibody responses to group 1 stem...
3.
Andrews S, Cominsky L, Shimberg G, Gillespie R, Gorman J, Raab J, et al.
Sci Transl Med
. 2023 Apr;
15(692):eade4976.
PMID: 37075126
Current yearly seasonal influenza vaccines primarily induce an antibody response directed against the immunodominant but continually diversifying hemagglutinin (HA) head region. These antibody responses provide protection against the vaccinating strain...
4.
Shen Y, Jung J, Shimberg G, Hsu F, Suryo Rahmanto Y, Gaillard S, et al.
iScience
. 2021 Nov;
24(11):103297.
PMID: 34816098
PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. is localized at chr1q23.3, a frequently amplified chromosomal region, and it is...
5.
Pritts J, Oluyadi A, Huang W, Shimberg G, Kane M, Wilks A, et al.
Biochemistry
. 2021 Feb;
60(10):780-790.
PMID: 33615774
Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that regulates pre-mRNA processing. CPSF30 contains five CCCH domains and one CCHC domain and recognizes two conserved 3'...
6.
Lange M, Ok K, Shimberg G, Bursac B, Marko L, Ivanovic-Burmazovic I, et al.
Angew Chem Int Ed Engl
. 2019 Mar;
58(24):7997-8001.
PMID: 30924279
H S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P-SSH). One family of proteins modified by H S are zinc finger (ZF) proteins,...
7.
Shimberg G, Pritts J, Michel S
Methods Enzymol
. 2018 May;
599:101-137.
PMID: 29746237
Zinc finger (ZF) proteins are proteins that use zinc as a structural cofactor. The common feature among all ZFs is that they contain repeats of four cysteine and/or histidine residues...
8.
Shimberg G, Ok K, Neu H, Splan K, Michel S
Inorg Chem
. 2017 May;
56(12):6838-6848.
PMID: 28557421
Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in regulating inflammatory response. TTP regulates cytokines at the mRNA level by binding to AU-rich sequences...
9.
Raibaut L, Vasseur W, Shimberg G, Saint-Pierre C, Ravanat J, Michel S, et al.
Chem Sci
. 2017 Apr;
8(2):1658-1664.
PMID: 28451295
We report the design of a luminescent sensor based upon the zinc finger (ZF) protein TIS11d, that allows for the selective time-resolved detection of the UUAUUUAUU sequence of the 3'-untranslated...
10.
Shimberg G, Michalek J, Oluyadi A, Rodrigues A, Zucconi B, Neu H, et al.
Proc Natl Acad Sci U S A
. 2016 Apr;
113(17):4700-5.
PMID: 27071088
Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys3His domains (annotated as "zinc-finger" domains). Using inductively coupled plasma mass spectrometry,...