Geoffrey A Smith
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Explore the profile of Geoffrey A Smith including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
142
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0
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Recent Articles
1.
Chorba J, Xia V, Smith G, Padmanabhan A
Bio Protoc
. 2023 Feb;
13(2).
PMID: 36789164
Genome-wide CRISPR-based screening is a powerful tool in forward genetics, enabling biologic discovery by linking a desired phenotype to a specific genetic perturbation. However, hits from a genome-wide screen require...
2.
Smith G, Padmanabhan A, Lau B, Pampana A, Li L, Lee C, et al.
Sci Transl Med
. 2022 Sep;
14(662):eabj8670.
PMID: 36103516
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States....
3.
Rezvani M, Smith G, Majzoub J, Durbin A, Winn A
Acad Pediatr
. 2021 Feb;
21(4):759-761.
PMID: 33607328
No abstract available.
4.
Smith G, Levinson A, Galvin R, Lalor L, McCalmont T, Wang L, et al.
J Pediatr Hematol Oncol
. 2020 Aug;
43(6):e791-e794.
PMID: 32852399
Subcutaneous panniculitis-like T-cell lymphoma is a cutaneous lymphoma characterized by CD8+ T-cell infiltrate in the subcutis that is rare in children. Acute lymphoblastic lymphoma is the most common pediatric malignancy...
5.
Lam C, Ferguson I, Mariano M, Lin Y, Murnane M, Liu H, et al.
Haematologica
. 2018 Apr;
103(7):1218-1228.
PMID: 29622655
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes....
6.
Smith G, Taunton J, Weiss A
Sci Signal
. 2017 Dec;
10(510).
PMID: 29259099
Interleukin-2 (IL-2) stimulates both activated CD4 and CD8 T cells to proliferate. IL-2 signals through an identical receptor complex and promotes the same dose-dependent phosphorylation of the canonical transcription factor...
7.
Yang Z, Robinson M, Chen X, Smith G, Taunton J, Liu W, et al.
Elife
. 2016 Dec;
5.
PMID: 27935477
IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE B cells are constrained by chronic activity of the IgE...
8.
Smith G, Uchida K, Weiss A, Taunton J
Nat Chem Biol
. 2016 Mar;
12(5):373-9.
PMID: 27018889
To drive lymphocyte proliferation and differentiation, common γ-chain (γc) cytokine receptors require hours to days of sustained stimulation. JAK1 and JAK3 kinases are found together in all γc-receptor complexes, but...
9.
Carelli J, Sethofer S, Smith G, Miller H, Simard J, Merrick W, et al.
Elife
. 2015 Dec;
4.
PMID: 26651998
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we...