Geoffrey A Neale
Overview
Explore the profile of Geoffrey A Neale including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
771
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Recent Articles
1.
Machado E, van de Vlekkert D, Sheppard H, Perry S, Downing S, Laxton J, et al.
Commun Biol
. 2022 Sep;
5(1):992.
PMID: 36127469
Rhabdomyosarcoma, the most common pediatric sarcoma, has no effective treatment for the pleomorphic subtype. Still, what triggers transformation into this aggressive phenotype remains poorly understood. Here we used Ptch1/ETV7 mice...
2.
Wilson C, Liu W, Yang J, Guolian Kang , Ojha R, Neale G, et al.
Cancer
. 2015 May;
121(13):2262-70.
PMID: 25963547
Background: The objective of this study was to identify treatment and genetic factors associated with obesity among childhood cancer survivors. Methods: Participants included 1996 survivors who previously received treatment for...
3.
Creamer K, Job G, Shanker S, Neale G, Lin Y, Bartholomew B, et al.
Mol Cell Biol
. 2014 Mar;
34(11):2046-61.
PMID: 24662054
Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/histone deacetylase (HDAC) repressor complex (SHREC) and is known to repress transcription at regions of heterochromatin. However, how Mit1...
4.
Seth A, Ye J, Yu N, Guez F, Bedford D, Neale G, et al.
Development
. 2014 Jan;
141(3):538-47.
PMID: 24449835
The liver has multiple functions that preserve homeostasis. Liver diseases are debilitating, costly and often result in death. Elucidating the developmental mechanisms that establish the liver's architecture or generate the...
5.
Baker S, Zimmerman E, Wang Y, Orwick S, Zatechka D, Buaboonnam J, et al.
Clin Cancer Res
. 2013 Aug;
19(20):5758-68.
PMID: 23969938
Purpose: To evaluate the clinical activity of sequential therapy with sorafenib and sunitinib in FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD)-positive acute myelogenous leukemia (AML) and monitor the emergence...
6.
Flanagan J, Sheehan V, Linder H, Howard T, Wang Y, Hoppe C, et al.
Blood
. 2013 Feb;
121(16):3237-45.
PMID: 23422753
Stroke is a devastating complication of sickle cell anemia (SCA), occurring in 11% of patients before age 20 years. Previous studies of sibling pairs have demonstrated a genetic component to...
7.
Ippagunta S, Malireddi R, Shaw P, Neale G, Vande Walle L, Fukui Y, et al.
Nat Immunol
. 2012 Aug;
13(7):701-2.
PMID: 22905357
No abstract available.
8.
Flanagan J, Steward S, Howard T, Mortier N, Kimble A, Aygun B, et al.
Br J Haematol
. 2012 Feb;
157(2):240-8.
PMID: 22360576
Sickle cell anaemia (SCA) is a severe debilitating haematological disorder associated with a high degree of morbidity and mortality. The level of fetal haemoglobin (HbF) is well-recognized as a critical...
9.
Ippagunta S, Malireddi R, Shaw P, Neale G, Vande Walle L, Green D, et al.
Nat Immunol
. 2011 Sep;
12(10):1010-6.
PMID: 21892172
The adaptor ASC contributes to innate immunity through the assembly of inflammasome complexes that activate the cysteine protease caspase-1. Here we demonstrate that ASC has an inflammasome-independent, cell-intrinsic role in...
10.
Stienstra R, van Diepen J, Tack C, Zaki M, van de Veerdonk F, Perera D, et al.
Proc Natl Acad Sci U S A
. 2011 Aug;
108(37):15324-9.
PMID: 21876127
Inflammation plays a key role in the pathogenesis of obesity. Chronic overfeeding leads to macrophage infiltration in the adipose tissue, resulting in proinflammatory cytokine production. Both microbial and endogenous danger...