Geoff Yu Zhang
Overview
Explore the profile of Geoff Yu Zhang including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
234
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Recent Articles
11.
Wang Y, Wang Y, Wang Y, Zheng G, Zhang G, Zhou J, et al.
Kidney Int
. 2012 Dec;
83(2):223-32.
PMID: 23223173
The CD40-CD154 costimulatory pathway has been shown to be critical for both T- and B-cell activation in autoimmune disease. Here, we assessed the effects of blocking this pathway using CD40...
12.
Wang Y, McRae J, Robson S, Cowan P, Zhang G, Hu M, et al.
Eur J Immunol
. 2012 Jun;
42(9):2441-51.
PMID: 22684996
CD39 is an ecto-enzyme that degrades extracellular nucleotides, such as ATP, and is highly expressed on by the vasculature and circulating cells including Foxp3+ regulatory T (Treg) cells. To study...
13.
Polhill T, Zhang G, Hu M, Sawyer A, Zhou J, Saito M, et al.
J Am Soc Nephrol
. 2012 Jun;
23(8):1303-8.
PMID: 22677553
Regulatory T cells (Tregs) help protect against autoimmune renal injury. The use of agonist antibodies and antibody/cytokine combinations to expand Tregs in vivo may have therapeutic potential for renal disease....
14.
Wang Y, Zhang G, Hu M, Polhill T, Sawyer A, Zhou J, et al.
J Am Soc Nephrol
. 2012 Apr;
23(6):1058-67.
PMID: 22491420
Autoreactive T cells play a pivotal role in the pathogenesis of autoimmune kidney disease. T cell vaccination (TCV) may limit autoimmune disease and induce CD8+ regulatory T cells (Tregs). We...
15.
Zhou J, Wang Y, Lee V, Phoon R, Zhang G, Wang Y, et al.
Int J Clin Exp Med
. 2012 Feb;
5(1):24-33.
PMID: 22328945
Monocytes utilise a variety of chemokines to traffic to atherosclerotic plaques. CX3C chemokine ligand 1 (CX3CL1 & Fractalkine) and its receptor CX3CR1 and monocyte chemoattractant protein 1 (CCL2) have been...
16.
Wang Y, Hu M, Wang Y, Polhill T, Zhang G, Wang Y, et al.
Int J Clin Exp Med
. 2008 Dec;
1(4):294-304.
PMID: 19079673
Regulatory T cells (Tregs) have a key role in immune homeostasis and in suppressing unwanted inflammatory responses toward self-antigens. Tregs have been implicated in the control of initial activation events,...
17.
Wu H, Wang Y, Wang Y, Hu M, Zhang G, Knight J, et al.
J Am Soc Nephrol
. 2007 Mar;
18(4):1180-9.
PMID: 17329577
It has been reported that the presence of gammadelta T cells in kidney is associated with kidney damage in human IgA nephropathy and in rat models of chronic renal injury,...
18.
Wang Y, Zhang G, Wang Y, Hu M, Wu H, Watson D, et al.
J Am Soc Nephrol
. 2006 Feb;
17(3):697-706.
PMID: 16467443
Chronic proteinuric renal injury is a major cause of ESRD. Adriamycin nephropathy is a murine model of chronic proteinuric renal disease whereby chemical injury is followed by immune and structural...
19.
Watson D, Zhang G, Sartor M, Alexander S
J Immunol
. 2004 Nov;
173(11):6574-82.
PMID: 15557147
Removal of alloreactive cells by either thymic deletion or deletion/anergy in the periphery is regarded as crucial to the development of tolerance. Dyes, such as CFSE, that allow monitoring of...