Geoff Dumsday
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Explore the profile of Geoff Dumsday including associated specialties, affiliations and a list of published articles.
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20
Citations
126
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Recent Articles
1.
Lu Z, Shen Q, Liu L, Talbo G, Speight R, Trau M, et al.
Eng Microbiol
. 2024 Dec;
3(3):100079.
PMID: 39628925
Hexokinase II (Hxk2) is a master protein in glucose-mediated transcriptional repression signaling pathway. Degrading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene (nerolidol) production at gram-per-liter levels in ....
2.
Lu Z, Shen Q, Bandari N, Evans S, McDonnell L, Liu L, et al.
Nucleic Acids Res
. 2024 May;
52(12):7367-7383.
PMID: 38808673
Temperature is an important control factor for biologics biomanufacturing in precision fermentation. Here, we explored a highly responsive low temperature-inducible genetic system (LowTempGAL) in the model yeast Saccharomyces cerevisiae. Two...
3.
Suri A, Hu K, Younas T, Dumsday G, Haritos V
Small
. 2024 Apr;
20(33):e2308463.
PMID: 38566530
Lipid droplets (LD) are dynamic cellular organelles of ≈1 µm diameter in yeast where a neutral lipid core is surrounded by a phospholipid monolayer and attendant proteins. Beyond the storage...
4.
Hu K, Suri A, Dumsday G, Haritos V
Nat Commun
. 2024 Jan;
15(1):418.
PMID: 38200012
Cellular heterogeneity in cell populations of isogenic origin is driven by intrinsic factors such as stochastic gene expression, as well as external factors like nutrient availability and interactions with neighbouring...
5.
Peng B, Weintraub S, Lu Z, Evans S, Shen Q, McDonnell L, et al.
ACS Synth Biol
. 2023 Dec;
13(1):141-156.
PMID: 38084917
The variability in phenotypic outcomes among biological replicates in engineered microbial factories presents a captivating mystery. Establishing the association between phenotypic variability and genetic drivers is important to solve this...
6.
Balu R, Wanasingha N, Mata J, Rekas A, Barrett S, Dumsday G, et al.
Sci Adv
. 2022 Dec;
8(51):eabq2202.
PMID: 36542701
The consequences of crowding on the dynamic conformational ensembles of intrinsically disordered proteins (IDPs) remain unresolved because of their ultrafast motion. Here, we report crowder-induced interactions and conformational dynamics of...
7.
Zou Z, Younas T, Dumsday G, Haritos V, He L
Biotechnol J
. 2022 Nov;
18(3):e2200390.
PMID: 36427490
RNA aptamers bind specifically and selectively to various macromolecules, cell surfaces, and viruses and find broad applications as biosensors, diagnostics, and in therapeutic treatments and drug delivery. Currently, RNA aptamer...
8.
Peng B, Esquirol L, Lu Z, Shen Q, Cheah L, Howard C, et al.
Nat Commun
. 2022 May;
13(1):2895.
PMID: 35610221
Bottlenecks in metabolic pathways due to insufficient gene expression levels remain a significant problem for industrial bioproduction using microbial cell factories. Increasing gene dosage can overcome these bottlenecks, but current...
9.
Peng B, Bandari N, Lu Z, Howard C, Scott C, Trau M, et al.
Commun Biol
. 2022 Feb;
5(1):135.
PMID: 35173283
Temporal control of heterologous pathway expression is critical to achieve optimal efficiency in microbial metabolic engineering. The broadly-used GAL promoter system for engineered yeast (Saccharomyces cerevisiae) suffers from several drawbacks;...
10.
Hayat I, Plan M, Ebert B, Dumsday G, Vickers C, Peng B
Microb Biotechnol
. 2021 Sep;
14(6):2627-2642.
PMID: 34499421
The yeast Saccharomyces cerevisiae uses the pyruvate dehydrogenase-bypass for acetyl-CoA biosynthesis. This relatively inefficient pathway limits production potential for acetyl-CoA-derived biochemical due to carbon loss and the cost of two...