Claudia E Vickers
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Explore the profile of Claudia E Vickers including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Lu Z, Shen Q, Liu L, Talbo G, Speight R, Trau M, et al.
Eng Microbiol
. 2024 Dec;
3(3):100079.
PMID: 39628925
Hexokinase II (Hxk2) is a master protein in glucose-mediated transcriptional repression signaling pathway. Degrading Hxk2 through an auxin-inducible protein degradation previously doubled sesquiterpene (nerolidol) production at gram-per-liter levels in ....
2.
McDonnell L, Evans S, Lu Z, Suchoronczak M, Leighton J, Ordeniza E, et al.
Synth Syst Biotechnol
. 2024 Jul;
9(4):820-827.
PMID: 39072146
In synthetic biology, microbial chassis including yeast are iteratively engineered with increasing complexity and scale. Wet-lab genetic engineering tools are developed and optimised to facilitate strain construction but are often...
3.
Cheah L, Sainsbury F, Vickers C
Methods Enzymol
. 2024 Jun;
699:121-161.
PMID: 38942501
The step catalyzed by terpene synthases is a well-recognized and significant bottleneck in engineered terpenoid bioproduction. Consequently, substantial efforts have been devoted towards increasing metabolic flux catalyzed by terpene synthases,...
4.
Perez-Gil J, Behrendorff J, Douw A, Vickers C
Nat Commun
. 2024 Jun;
15(1):5303.
PMID: 38906898
The methylerythritol phosphate (MEP) pathway is responsible for biosynthesis of the precursors of isoprenoid compounds in eubacteria and plastids. It is a metabolic alternative to the well-known mevalonate pathway for...
5.
Lu Z, Shen Q, Bandari N, Evans S, McDonnell L, Liu L, et al.
Nucleic Acids Res
. 2024 May;
52(12):7367-7383.
PMID: 38808673
Temperature is an important control factor for biologics biomanufacturing in precision fermentation. Here, we explored a highly responsive low temperature-inducible genetic system (LowTempGAL) in the model yeast Saccharomyces cerevisiae. Two...
6.
Loan T, Vickers C, Ayliffe M, Luo M
ACS Synth Biol
. 2024 Mar;
13(5):1492-1497.
PMID: 38525720
Ruminant livestock produce around 24% of global anthropogenic methane emissions. Methanogenesis in the animal rumen is significantly inhibited by bromoform, which is abundant in seaweeds of the genus . This...
7.
Peng B, Weintraub S, Lu Z, Evans S, Shen Q, McDonnell L, et al.
ACS Synth Biol
. 2023 Dec;
13(1):141-156.
PMID: 38084917
The variability in phenotypic outcomes among biological replicates in engineered microbial factories presents a captivating mystery. Establishing the association between phenotypic variability and genetic drivers is important to solve this...
8.
Cheah L, Liu L, Plan M, Peng B, Lu Z, Schenk G, et al.
Adv Sci (Weinh)
. 2023 Sep;
10(32):e2303415.
PMID: 37750486
Enzyme spatial organization is an evolved mechanism for facilitating multi-step biocatalysis and can play an important role in the regulation of promiscuous enzymes. The latter function suggests that artificial spatial...
9.
Development of epistatic YES and AND protein logic gates and their assembly into signalling cascades
Guo Z, Smutok O, Ayva C, Walden P, Parker J, Whitfield J, et al.
Nat Nanotechnol
. 2023 Jul;
18(11):1327-1334.
PMID: 37500780
The construction and assembly of artificial allosteric protein switches into information and energy processing networks connected to both biological and non-biological systems is a central goal of synthetic biology and...
10.
Cheah L, Liu L, Stark T, Plan M, Peng B, Lu Z, et al.
Metab Eng
. 2023 Mar;
77:143-151.
PMID: 36990382
The end-to-end fusion of enzymes that catalyse successive steps in a reaction pathway is a metabolic engineering strategy that has been successfully applied in a variety of pathways and is...