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Gengze Wei

Explore the profile of Gengze Wei including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 205
Followers 0
Related Specialties
Neurology
Pharmacology
Biochemistry
Top 10 Co-Authors
Brendan M Walker
Jun Xu
Bok Soon Go
Gaetan Lepreux
Sunil Sirohi
Chloe M Erikson
Xinxian Deng
Galina N Filippova
Angela M Henricks
Zixu Mao
Published In
Neuropharmacology
J Biol Chem
Genome Biol
Addict Biol
J Mol Neurosci
Affiliations
Soon will be listed here.
Recent Articles
1.
Kappa-opioid receptor antagonism in the nucleus accumbens shell distinguishes escalated alcohol consumption and negative affective-like behavior from physiological withdrawal in alcohol-dependence
Lepreux G, Henricks A, Wei G, Go B, Erikson C, Abella R, et al.
Pharmacol Biochem Behav . 2024 Aug; 243():173840. PMID: 39096973
Alcohol use disorder (AUD) is a chronic relapsing disease that is deleterious at individual, familial, and societal levels. Although AUD is one of the highest preventable causes of death in...
2.
Recapitulating phenotypes of alcohol dependence via overexpression of Oprk1 in the ventral tegmental area of non-dependent TH::Cre rats
Lepreux G, Shinn G, Wei G, Suko A, Concepcion G, Sirohi S, et al.
Neuropharmacology . 2023 Feb; 228:109457. PMID: 36764577
The dynorphin (DYN)/kappa-opioid receptor (KOR) system is involved in dysphoria and negative emotional states. Dysregulation of KOR function promotes maladaptive behavioral regulation during withdrawal associated with alcohol dependence. Mesolimbic dopaminergic...
3.
Dysregulated kappa-opioid receptors in the medial prefrontal cortex contribute to working memory deficits in alcohol dependence
Wei G, Sirohi S, Walker B
Addict Biol . 2022 Feb; 27(2):e13138. PMID: 35138672
Impaired working memory is one symptom contributing to compromised executive function in alcohol use disorder (AUD). Dysregulation of cortical dynorphin (DYN) and κ-opioid receptors (KORs) has been implicated in alcohol...
4.
Maladaptive behavioral regulation in alcohol dependence: Role of kappa-opioid receptors in the bed nucleus of the stria terminalis
Erikson C, Wei G, Walker B
Neuropharmacology . 2018 Aug; 140:162-173. PMID: 30075159
There is an important emerging role for the endogenous opioid dynorphin (DYN) and the kappa-opioid receptor (KOR) in the treatment of alcohol dependence. Evidence suggests that the DYN/KOR system in...
5.
Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells
Wei G, Deng X, Agarwal S, Iwase S, Disteche C, Xu J
J Mol Neurosci . 2016 Jul; 60(1):33-45. PMID: 27421841
The X-linked lysine (K)-specific demethylase 5C (KDM5C) gene plays an important role in brain development and behavior. It encodes a histone demethylase that is involved in gene regulation in neuronal...
6.
The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation
Yang F, Deng X, Ma W, Berletch J, Rabaia N, Wei G, et al.
Genome Biol . 2015 Apr; 16:52. PMID: 25887447
Background: In mammals, X chromosome genes are present in one copy in males and two in females. To balance the dosage of X-linked gene expression between the sexes, one of...
7.
Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors
Wei G, Yin Y, Li W, Bito H, She H, Mao Z
J Biol Chem . 2012 Jan; 287(8):5797-805. PMID: 22215669
Synaptic and extrasynaptic NMDA receptors (NMDARs) appear to play opposite roles in neuronal survival and death. Here we report the new findings on the dysregulation of survival factor, myocyte enhancer...