Genevieve Stein-OBrien
Overview
Explore the profile of Genevieve Stein-OBrien including associated specialties, affiliations and a list of published articles.
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27
Citations
450
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Recent Articles
1.
Sidiropoulos D, Shin S, Wetzel M, Girgis A, Bergman D, Danilova L, et al.
bioRxiv
. 2024 Oct;
PMID: 39386736
Graphical Abstract: Highlights: Integrated multi-modal spatial profiling of human PDAC tumors from neoadjuvant immunotherapy clinical trials reveal diverse spatial niches enriched in TLS.TLS maturity is influenced by tumor location and...
2.
Godet I, Oza H, Shi Y, Joe N, Weinstein A, Johnson J, et al.
Nat Commun
. 2024 Sep;
15(1):8416.
PMID: 39341835
Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in...
3.
West J, Golloshi R, Cho C, Wang Y, Stevenson P, Stein-OBrien G, et al.
J Cell Biol
. 2024 Sep;
223(12).
PMID: 39320351
Metastasis initiates when cancer cells escape from the primary tumor, which requires changes to intercellular junctions. Claudins are transmembrane proteins that form the tight junction, and their expression is reduced...
4.
Barao S, Xu Y, Llongueras J, Vistein R, Goff L, Nielsen K, et al.
Nat Commun
. 2024 Sep;
15(1):8043.
PMID: 39271675
The neocortex varies in size and complexity among mammals due to the tremendous variability in the number and diversity of neuronal subtypes across species. The increased cellular diversity is paralleled...
5.
Kim S, Seo S, Stein-OBrien G, Jaishankar A, Ogawa K, Micali N, et al.
Stem Cell Reports
. 2024 Aug;
19(9):1336-1350.
PMID: 39151428
Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. In this study, hPSC lines from multiple donors were differentiated toward neuroectoderm and mesendoderm lineages....
6.
Wang Y, Woyshner K, Sriworarat C, Stein-OBrien G, Goff L, Hansen K
bioRxiv
. 2024 Jul;
PMID: 39005356
Analyzing multi-sample spatial transcriptomics data requires accounting for biological variation. We present multi-sample non-negative spatial factorization (mNSF), an alignment-free framework extending single-sample spatial factorization (NSF) to multi-sample datasets. mNSF incorporates...
7.
Guinn S, Kinny-Koster B, Tandurella J, Mitchell J, Sidiropoulos D, Loth M, et al.
Cancer Res
. 2024 Apr;
84(9):1517-1533.
PMID: 38587552
Significance: Adaptation of transfer learning to relate human single-cell RNA sequencing data to organoid-CAF cocultures facilitates discovery of human pancreatic cancer intercellular interactions and uncovers cross-talk between CAFs and tumor...
8.
Sonthalia S, Adkins R, Orvis J, Li G, Mato Blanco X, Casella A, et al.
bioRxiv
. 2024 Mar;
PMID: 38464021
Vast quantities of multi-omic data have been produced to characterize the development and diversity of cell types in the cerebral cortex of humans and other mammals. To more fully harness...
9.
Barao S, Xu Y, Llongueras J, Vistein R, Goff L, Nielsen K, et al.
bioRxiv
. 2023 Nov;
PMID: 37961182
The mammalian neocortex differs vastly in size and complexity between mammalian species, yet the mechanisms that lead to an increase in brain size during evolution are not known. We show...
10.
Zheng S, Stein-OBrien G, Boukas L, Goff L, Hansen K
Genome Biol
. 2023 Oct;
24(1):246.
PMID: 37885016
Background: RNA velocity analysis of single cells offers the potential to predict temporal dynamics from gene expression. In many systems, RNA velocity has been observed to produce a vector field...