Gene I Uenishi
Overview
Explore the profile of Gene I Uenishi including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
251
Followers
0
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Recent Articles
1.
Uenishi G, Repic M, Yam J, Landuyt A, Saikumar-Lakshmi P, Guo T, et al.
JCI Insight
. 2024 Mar;
9(6).
PMID: 38516892
Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving β cell function. Adoptive transfer of autologous thymic Tregs, although...
2.
Cook P, Yang S, Uenishi G, Grimm A, West S, Wang L, et al.
Mol Ther
. 2023 May;
31(8):2472-2488.
PMID: 37147803
Engineered T cells represent an emerging therapeutic modality. However, complex engineering strategies can present a challenge for enriching and expanding therapeutic cells at clinical scale. In addition, lack of in ...
3.
Uenishi G, Jung H, Slukvin I
Methods Mol Biol
. 2022 May;
2429:103-124.
PMID: 35507158
Endothelial-to-hematopoietic transition (EHT) is a unique morphogenic event in which flat, adherent hemogenic endothelial (HE) cells acquire round, non-adherent blood cell morphology. Investigating the mechanisms of EHT is critical for...
4.
Bloor A, Patel A, Griffin J, Gilleece M, Radia R, Yeung D, et al.
Nat Med
. 2020 Sep;
26(11):1720-1725.
PMID: 32929265
The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been investigated in diverse diseases, including steroid-resistant acute graft versus host disease (SR-aGvHD). However, conventional manufacturing approaches are hampered by...
5.
Slukvin I, Uenishi G
Exp Hematol
. 2018 Dec;
71:3-12.
PMID: 30500414
Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de novo production of blood cells for transfusion, immunotherapies, and transplantation. However, even with advanced hematopoietic...
6.
Uenishi G, Jung H, Kumar A, Park M, Hadland B, McLeod E, et al.
Nat Commun
. 2018 May;
9(1):1828.
PMID: 29739946
NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage...