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Gene C Webb

Explore the profile of Gene C Webb including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 114
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Recent Articles
1.
Vlacich G, Nawijn M, Webb G, Steiner D
Islets . 2010 Nov; 2(5):308-17. PMID: 21099329
Pancreatic β-cell response to glucose stimulation is governed by tightly regulated signaling pathways which have not been fully characterized. A screen for novel signaling intermediates identified Pim3 as a glucose-responsive...
2.
Wideman R, Gray S, Covey S, Webb G, Kieffer T
Mol Ther . 2008 Oct; 17(1):191-8. PMID: 18941442
Type 2 diabetes (T2D) is characterized by elevated blood glucose levels owing to insufficient secretion and/or activity of the glucose-lowering hormone insulin. Glucagon-like peptide-1 (GLP-1) has received much attention as...
3.
Wideman R, Covey S, Webb G, Drucker D, Kieffer T
Diabetes . 2007 Aug; 56(11):2744-52. PMID: 17698597
Objective: Glucagon, which raises blood glucose levels by stimulating hepatic glucose production, is produced in alpha-cells via cleavage of proglucagon by prohormone convertase (PC)-2. In the enteroendocrine L-cell, proglucagon is...
4.
Vlacich G, Roe C, Webb G
Nat Clin Pract Endocrinol Metab . 2007 Jul; 3(8):594-605. PMID: 17643130
For microarrays, the transition from research to clinical and diagnostic applications is well underway. Microarrays use a range of specific probes that are immobilized in known locations on a support...
5.
Rolny C, Lu L, Agren N, Nilsson I, Roe C, Webb G, et al.
Exp Cell Res . 2005 May; 308(2):381-93. PMID: 15919073
The mechanisms controlling blood vessel formation during early embryonal development have only partly been elucidated. Shb is an adaptor protein previously implicated in the angiogenic response to vascular endothelial growth...
6.
Webb G, Dey A, Wang J, Stein J, Milewski M, Steiner D
J Biol Chem . 2004 May; 279(30):31068-75. PMID: 15143067
The endoproteolytic processing of proproteins in the secretory pathway depends on the expression of selected members of a family of subtilisin-like endoproteases known as the prohormone convertases (PCs). The main...
7.
Webb G, Akbar M, Zhao C, Swift H, Steiner D
Diabetes . 2002 Jan; 51(2):398-405. PMID: 11812747
Prohormone convertase 2 (PC2) plays an essential role in the processing of proglucagon to mature active glucagon in pancreatic alpha-cells (J Biol Chem 276:27197-27202, 2001). Mice lacking PC2 demonstrate multiple...