Geetika Aggarwal
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Explore the profile of Geetika Aggarwal including associated specialties, affiliations and a list of published articles.
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32
Citations
178
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Recent Articles
1.
Smith D, Aggarwal G, Niehoff M, Jones S, Banerjee S, Farr S, et al.
Mol Neurobiol
. 2024 May;
61(11):9708-9722.
PMID: 38696065
Heterozygous loss-of-function mutations in the progranulin gene (GRN) are a major cause of frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of progranulin causes neuronal ceroid lipofuscinosis. Several progranulin-deficient mouse...
2.
Aggarwal G, Banerjee S, Jones S, Benchaar Y, Belanger J, Sevigny M, et al.
J Biol Chem
. 2023 Nov;
299(12):105475.
PMID: 37981208
Heterozygous GRN (progranulin) mutations cause frontotemporal dementia (FTD) due to haploinsufficiency, and increasing progranulin levels is a major therapeutic goal. Several microRNAs, including miR-29b, negatively regulate progranulin protein levels. Antisense...
3.
Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance
Aggarwal G, Malmstrom T, Morley J, Miller D, Nguyen A, Butler A
NPJ Aging
. 2023 Nov;
9(1):24.
PMID: 37945652
We recently reported accelerated cognitive decline in Europeans aged > 70 years with low circulating adropin levels. Adropin is a small, secreted peptide that is highly expressed in the human...
4.
Rai S, Mago Y, Aggarwal G, Yadav A, Tewari S
Mol Biotechnol
. 2023 Nov;
66(10):2725-2750.
PMID: 37923941
The human population is expanding at an exponential rate, and has created a great surge in the demand for food production. To intensify the rate of crop production, there is...
5.
Smith D, Aggarwal G, Niehoff M, Jones S, Banerjee S, Farr S, et al.
bioRxiv
. 2023 Jul;
PMID: 37398305
Heterozygous loss-of-function mutations in the progranulin gene () are a major cause of frontotemporal dementia due to progranulin haploinsufficiency; complete deficiency of progranulin causes neuronal ceroid lipofuscinosis. Several progranulin-deficient mouse...
6.
Aggarwal G, Morley J, Vellas B, Nguyen A, Butler A
Geroscience
. 2023 May;
46(1):897-911.
PMID: 37233882
The secreted peptide adropin is highly expressed in human brain tissues and correlates with RNA and proteomic risk indicators for dementia. Here we report that plasma adropin concentrations predict risk...
7.
Virecoulon Giudici K, De Souto Barreto P, Guyonnet S, Morley J, Nguyen A, Aggarwal G, et al.
J Gerontol A Biol Sci Med Sci
. 2022 Dec;
78(4):569-578.
PMID: 36508390
There is growing evidence that cognitive decline can be affected by both nutritional aspects and inflammation. Plasma neurodegenerative biomarkers stand out as minimally invasive useful measures to monitor the potential...
8.
Boland S, Swarup S, Ambaw Y, Malia P, Richards R, Fischer A, et al.
Nat Commun
. 2022 Oct;
13(1):5924.
PMID: 36207292
Haploinsufficiency of GRN causes frontotemporal dementia (FTD). The GRN locus produces progranulin (PGRN), which is cleaved to lysosomal granulin polypeptides. The function of lysosomal granulins and why their absence causes...
9.
Dedert C, Mishra V, Aggarwal G, Nguyen A, Xu F
Front Cell Neurosci
. 2022 Jul;
16:874258.
PMID: 35880011
Chronic hyperglycemia in type II diabetes results in impaired autophagy function, accumulation of protein aggregates, and neurodegeneration. However, little is known about how to preserve autophagy function under hyperglycemic conditions....
10.
Nguyen A, Malmstrom T, Aggarwal G, Miller D, Vellas B, Morley J
EBioMedicine
. 2022 Jul;
82:104146.
PMID: 35830835
Background: Blood biomarkers can offer valuable and easily accessible indicators of normal biological processes, pathogenic conditions, and responses to therapeutic interventions. Recent studies found that levels of neurofilament light chain...