Geert A A Nibourg
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Explore the profile of Geert A A Nibourg including associated specialties, affiliations and a list of published articles.
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10
Citations
237
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Recent Articles
1.
Nibourg G, Hoekstra R, van der Hoeven T, Ackermans M, Hakvoort T, van Gulik T, et al.
Int J Biochem Cell Biol
. 2013 Jun;
45(8):1860-8.
PMID: 23770120
The clinical application of a bioartificial liver (BAL) depends on the availability of a human cell source with high hepatic functionality, such as the human hepatoma cell line HepaRG. This...
2.
Nibourg G, Hoekstra R, van der Hoeven T, Ackermans M, Hakvoort T, van Gulik T, et al.
Liver Int
. 2013 Feb;
33(4):516-24.
PMID: 23387413
Background & Aims: The AMC-bioartificial liver loaded with the human hepatoma cell line HepaRG as biocomponent (HepaRG-AMC-BAL) has recently proven efficacious in rats with acute liver failure (ALF). However, its...
3.
Hoekstra R, Nibourg G, van der Hoeven T, Plomer G, Seppen J, Ackermans M, et al.
Drug Metab Dispos
. 2012 Dec;
41(3):562-7.
PMID: 23238784
The human liver cell line HepaRG has been recognized as a promising source for in vitro testing of metabolism and toxicity of compounds. However, currently the hepatic differentiation of these...
4.
Hoekstra R, Nibourg G, van der Hoeven T, Ackermans M, Hakvoort T, van Gulik T, et al.
Int J Artif Organs
. 2012 Oct;
35(11):1006-14.
PMID: 23065880
Purpose: We recently demonstrated the high liver functionality of the human liver cell line HepaRG, including ammonia eliminating capacity, making it a valuable biocomponent of a bioartificial liver (BAL) to...
5.
Hoekstra L, de Graaf W, Nibourg G, Heger M, Bennink R, Stieger B, et al.
Ann Surg
. 2012 Jul;
257(1):27-36.
PMID: 22836216
Objective: To review the literature on the most clinically relevant and novel liver function tests used for the assessment of hepatic function before liver surgery. Background: Postoperative liver failure is...
6.
Nibourg G, Boer J, van der Hoeven T, Ackermans M, van Gulik T, Chamuleau R, et al.
Biotechnol Bioeng
. 2012 Jun;
109(12):3182-8.
PMID: 22729831
Bioartificial livers (BALs) are bioreactors containing liver cells that provide extracorporeal liver support to liver-failure patients. Theoretically, the plasma perfusion flow rate through a BAL is an important determinant of...
7.
Nibourg G, Chamuleau R, van der Hoeven T, Maas M, Ruiter A, Lamers W, et al.
PLoS One
. 2012 Jun;
7(6):e38778.
PMID: 22719943
A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human...
8.
Nibourg G, Chamuleau R, van Gulik T, Hoekstra R
Expert Opin Biol Ther
. 2012 Jun;
12(7):905-21.
PMID: 22650303
Introduction: Bioartificial livers (BALs) are urgently needed to bridge severe liver failure patients to liver transplantation or liver regeneration. When based on primary hepatocytes, their efficacy has been shown in...
9.
Hoekstra R, Nibourg G, van der Hoeven T, Ackermans M, Hakvoort T, van Gulik T, et al.
Int J Biochem Cell Biol
. 2011 Jul;
43(10):1483-9.
PMID: 21726661
For bioartificial liver application, cells should meet the following minimal requirements: ammonia elimination, drug metabolism and blood protein synthesis. Here we explore the suitability of HepaRG cells, a human cell...
10.
Nibourg G, Huisman M, van der Hoeven T, van Gulik T, Chamuleau R, Hoekstra R
Liver Transpl
. 2010 Sep;
16(9):1075-85.
PMID: 20818746
To bridge patients with acute liver failure to transplantation or liver regeneration, a bioartificial liver (BAL) is urgently needed. A BAL consists of an extracorporeal bioreactor loaded with a bioactive...