Ronald P Oude Elferink
Overview
Explore the profile of Ronald P Oude Elferink including associated specialties, affiliations and a list of published articles.
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25
Citations
590
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Recent Articles
1.
Bortolussi G, Shi X, Bloemendaal L, Banerjee B, de Waart D, Baj G, et al.
Antioxidants (Basel)
. 2021 Dec;
10(12).
PMID: 34943131
Accumulation of neurotoxic bilirubin due to a transient neonatal or persistent inherited deficiency of bilirubin glucuronidation activity can cause irreversible brain damage and death. Strategies to inhibit bilirubin production and...
2.
Shi X, Aronson S, Bloemendaal L, Duijst S, Bakker R, de Waart D, et al.
Mol Ther Methods Clin Dev
. 2021 Jan;
20:287-297.
PMID: 33511243
A clinical trial using adeno-associated virus serotype 8 (AAV8)-human uridine diphosphate glucuronosyltransferase 1A1 (h) to treat inherited severe unconjugated hyperbilirubinemia (Crigler-Najjar syndrome) is ongoing, but preclinical data suggest that long-term...
3.
van der Mark V, Adam A, Chang J, Elferink R, Chamuleau R, Hoekstra R
Toxicol Appl Pharmacol
. 2020 May;
399:115055.
PMID: 32428594
The liver cell line HepaRG is one of the preferred sources of human hepatocytes for in vitro applications. However, mitochondrial energy metabolism is relatively low, which affects hepatic functionality and...
4.
Adam A, Jongejan A, Moerland P, van der Mark V, Elferink R, Chamuleau R, et al.
Cytotechnology
. 2020 Mar;
72(3):377-395.
PMID: 32130581
Human liver cell line HepaRG is a well-known source of human hepatocyte-like cells which, however, displays limited biotransformation and a tendency to transform after 20 passages. The new HepaRG-CAR cell...
5.
Botschuijver S, van Diest S, van Thiel I, Saia R, Strik A, Yu Z, et al.
Sci Rep
. 2019 Aug;
9(1):12530.
PMID: 31467355
Irritable bowel syndrome (IBS) is a heterogenic, functional gastrointestinal disorder of the gut-brain axis characterized by altered bowel habit and abdominal pain. Preclinical and clinical results suggested that, in part...
6.
Dhillon A, Kremer A, Kummen M, Boberg K, Elferink R, Karlsen T, et al.
Sci Rep
. 2019 Jun;
9(1):8450.
PMID: 31186435
Autotaxin has been associated with liver disease severity and transplant-free survival. This study aimed to validate autotaxin as a biomarker in two cohorts of Norwegian large-duct PSC patients, one discovery...
7.
Aronson S, Bakker R, Shi X, Duijst S, Bloemendaal L, de Waart D, et al.
J Hepatol
. 2019 Apr;
71(1):153-162.
PMID: 30935993
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3), for which there are limited therapeutic options, often leads to end-stage liver disease before adulthood due to impaired ABCB4-dependent phospholipid...
8.
Macias R, Matilla S, Lozano E, Estiu M, Elferink R, Marin J
Am J Physiol Gastrointest Liver Physiol
. 2018 Jun;
315(3):G399-G407.
PMID: 29927323
Intrahepatic cholestasis of pregnancy (ICP) is frequently accompanied by pruritus, whose etiology has been associated with an enhanced production of lysophosphatidic acid (LPA) by the combined action of phospholipase A1/A2...
9.
van Wenum M, Adam A, van der Mark V, Chang J, Wildenberg M, Hendriks E, et al.
J Cell Commun Signal
. 2018 Feb;
12(3):575-588.
PMID: 29399736
The in vitro generation of terminally differentiated hepatocytes is an unmet need. We investigated the contribution of oxygen concentration to differentiation in human liver cell lines HepaRG and C3A. HepaRG...
10.
Erice O, Munoz-Garrido P, Vaquero J, Perugorria M, Fernandez-Barrena M, Saez E, et al.
Hepatology
. 2017 Sep;
67(4):1420-1440.
PMID: 28922472
Conclusion: Different proinflammatory cytokines enhance the expression of miR-506 in biliary epithelial cells; miR-506 induces PBC-like features in cholangiocytes and promotes immune activation, representing a potential therapeutic target for PBC...