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Gavin J Ryan

Explore the profile of Gavin J Ryan including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 329
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Recent Articles
1.
Ryan G, Shapiro H, Lenaerts A
Tuberculosis (Edinb) . 2014 Aug; 94(5):511-8. PMID: 25130623
Acid fast staining of sputum smears by microscopy remains the prevalent method for detecting Mycobacterium tuberculosis. The sensitivity of microscopy using acid fast stains requires 10(4) bacilli per ml of...
2.
Shi L, Ryan G, Bhamidi S, Troudt J, Amin A, Izzo A, et al.
Tuberculosis (Edinb) . 2014 Jul; 94(5):525-30. PMID: 25037320
Evidence suggests that Mycobacterium tuberculosis grown in vivo may have a different phenotypic structure from its in vitro counterpart. In order to study the differences between in vivo and in ...
3.
Driver E, Ryan G, Hoff D, Irwin S, Basaraba R, Kramnik I, et al.
Antimicrob Agents Chemother . 2012 Apr; 56(6):3181-95. PMID: 22470120
Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli...
4.
Dhiman R, Dinadayala P, Ryan G, Lenaerts A, Schenkel A, Crick D
J Bacteriol . 2011 Aug; 193(20):5802-9. PMID: 21840972
Lipoarabinomannan (LAM) is a structurally heterogeneous amphipathic lipoglycan present in Mycobacterium spp. and other actinomycetes, which constitutes a major component of the cell wall and exhibits a wide spectrum of...
5.
Hoff D, Ryan G, Driver E, Ssemakulu C, De Groote M, Basaraba R, et al.
PLoS One . 2011 Mar; 6(3):e17550. PMID: 21445321
The lengthy treatment regimen for tuberculosis is necessary to eradicate a small sub-population of M. tuberculosis that persists in certain host locations under drug pressure. Limited information is available on...
6.
Ryan G, Hoff D, Driver E, Voskuil M, Gonzalez-Juarrero M, Basaraba R, et al.
PLoS One . 2010 Jun; 5(6):e11108. PMID: 20559431
A unique hallmark of tuberculosis is the granulomatous lesions formed in the lung. Granulomas can be heterogeneous in nature and can develop a necrotic, hypoxic core which is surrounded by...
7.
Hoff D, Caraway M, Brooks E, Driver E, Ryan G, Peloquin C, et al.
Antimicrob Agents Chemother . 2008 Aug; 52(11):4137-40. PMID: 18694944
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in...