Gaurav Bedse
Overview
Explore the profile of Gaurav Bedse including associated specialties, affiliations and a list of published articles.
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27
Citations
732
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Recent Articles
1.
Daver N, Montesinos P, DeAngelo D, Wang E, Papadantonakis N, Todisco E, et al.
Lancet Oncol
. 2024 Feb;
25(3):388-399.
PMID: 38423051
Background: Pivekimab sunirine (IMGN632) is a first-in-class antibody-drug conjugate comprising a high-affinity CD123 antibody, cleavable linker, and novel indolinobenzodiazepine pseudodimer payload. CD123 is overexpressed in several haematological malignancies, including acute...
2.
Winters N, Bedse G, Astafyev A, Patrick T, Altemus M, Morgan A, et al.
J Clin Invest
. 2021 Jul;
PMID: 34292886
Alcohol use disorder (AUD) is associated with substantial morbidity, mortality, and societal cost, and pharmacological treatment options for AUD are limited. The endogenous cannabinoid (eCB) signaling system is critically involved...
3.
Bedse G, Hill M, Patel S
Biol Psychiatry
. 2020 Mar;
88(7):520-530.
PMID: 32197779
Over the past decade there has been a surge of interest in the development of endocannabinoid-based therapeutic approaches for the treatment of diverse neuropsychiatric conditions. Although initial preclinical and clinical...
4.
Marcus D, Bedse G, Gaulden A, Ryan J, Kondev V, Winters N, et al.
Neuron
. 2020 Jan;
105(6):1062-1076.e6.
PMID: 31948734
Functional coupling between the amygdala and the dorsomedial prefrontal cortex (dmPFC) has been implicated in the generation of negative affective states; however, the mechanisms by which stress increases amygdala-dmPFC synaptic...
5.
Morgan A, Kondev V, Bedse G, Baldi R, Marcus D, Patel S
Neurobiol Stress
. 2019 Aug;
11:100190.
PMID: 31467944
Chronic stress increases the probability of receiving an anxiety, depression, or chronic illness diagnosis. Pharmacological interventions that reduce the behavioral and physiological effects of chronic stress in animal models may...
6.
Centanni S, Bedse G, Patel S, Winder D
Alcohol Clin Exp Res
. 2019 Aug;
43(10):2000-2013.
PMID: 31403699
Alcohol use disorder (AUD) afflicts a large number of individuals, families, and communities globally. Affective disturbances, including stress, depression, and anxiety, are highly comorbid with AUD, contributing in some cases...
7.
Bedse G, Centanni S, Winder D, Patel S
Alcohol Clin Exp Res
. 2019 Aug;
43(10):2014-2027.
PMID: 31373708
High rates of relapse are a chronic and debilitating obstacle to effective treatment of alcohol use disorder (AUD); however, no effective treatments are available to treat symptoms induced by protracted...
8.
Centanni S, Morris B, Luchsinger J, Bedse G, Fetterly T, Patel S, et al.
Neuropsychopharmacology
. 2018 Nov;
44(3):526-537.
PMID: 30390064
Negative affect is a core symptom domain associated with an array of neurological and psychiatric disorders and is only partially targeted by current therapies, highlighting the need for better, more...
9.
Bedse G, Bluett R, Patrick T, Romness N, Gaulden A, Kingsley P, et al.
Transl Psychiatry
. 2018 Apr;
8(1):92.
PMID: 29695817
Recent studies have demonstrated anxiolytic potential of pharmacological endocannabinoid (eCB) augmentation approaches in a variety of preclinical models. Pharmacological inhibition of endocannabinoid-degrading enzymes, such as fatty acid amide hydrolase (FAAH)...
10.
Rathinasabapathy A, Horowitz A, Horton K, Kumar A, Gladson S, Unger T, et al.
Front Physiol
. 2018 Apr;
9:180.
PMID: 29636695
Idiopathic Pulmonary Fibrosis (IPF) is a chronic lung disease characterized by scar formation and respiratory insufficiency, which progressively leads to death. Pulmonary hypertension (PH) is a common complication of IPF...