Gaspard Cretenet
Overview
Explore the profile of Gaspard Cretenet including associated specialties, affiliations and a list of published articles.
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14
Citations
819
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Recent Articles
1.
Jacobs C, Peters F, Camerini E, Cretenet G, Rietveld J, Schomakers B, et al.
Cell Mol Immunol
. 2025 Mar;
PMID: 40033083
Autologous T-cell therapies show limited efficacy in chronic lymphocytic leukemia (CLL), where acquired immune dysfunction prevails. In CLL, disturbed mitochondrial metabolism has been linked to defective T-cell activation and proliferation....
2.
van Bruggen J, Peters F, Mes M, Rietveld J, Cerretani E, Cretenet G, et al.
Blood Adv
. 2024 Jul;
8(17):4633-4646.
PMID: 39042920
Autologous T-cell-based therapies, such as chimeric antigen receptor (CAR) T-cell therapy, exhibit low success rates in chronic lymphocytic leukemia (CLL) and correlate with a dysfunctional T-cell phenotype observed in patients....
3.
Montironi C, Chen Z, Derks I, Cretenet G, Krap E, Eldering E, et al.
iScience
. 2024 Apr;
27(5):109640.
PMID: 38680661
The tumor suppressor p53 has been described to control various aspects of metabolic reprogramming in solid tumors, but in B cell malignancies that role is as yet unknown. We generated...
4.
Montironi C, Jacobs C, Cretenet G, Peters F, Schomakers B, van Weeghel M, et al.
Blood Adv
. 2023 Aug;
7(21):6540-6552.
PMID: 37552122
Acquired T-cell dysfunction is common in chronic B-cell malignancies. Given the strong connection between T-cell metabolism and function, we investigated metabolic alterations as the basis of T-cell dysfunction induced by...
5.
Chen Z, Cretenet G, Carnazzo V, Simon-Molas H, Kater A, van der Windt G, et al.
Haematologica
. 2023 Jul;
109(1):151-162.
PMID: 37439352
CD40 signaling upregulates BCL-XL and MCL-1 expression in the chronic lymphocytic leukemia (CLL) lymph node microenvironment, affording resistance to the BCL-2 inhibitor, venetoclax. Venetoclax resistance in the therapeutic setting and...
6.
Chen Z, Simon-Molas H, Cretenet G, Valle-Argos B, Smith L, Forconi F, et al.
Blood
. 2022 Apr;
140(6):630-643.
PMID: 35486832
Altered metabolism is a hallmark of both cell division and cancer. Chronic lymphocytic leukemia (CLL) cells circulate between peripheral blood (PB) and lymph nodes (LNs), where they receive proliferative and...
7.
Kater A, Slinger E, Cretenet G, Martens A, Balasubramanian S, Leverson J, et al.
Blood Adv
. 2021 Sep;
5(23):5410-5414.
PMID: 34555843
The covalent inhibitor of Bruton's tyrosine kinase ibrutinib and the specific Bcl-2 inhibitor venetoclax are both highly efficacious single-agent drugs in the treatment of chronic lymphocytic leukemia (CLL). Based on...
8.
Resveratrol stimulates the metabolic reprogramming of human CD4 T cells to enhance effector function
Craveiro M, Cretenet G, Mongellaz C, Matias M, Caron O, de Lima M, et al.
Sci Signal
. 2017 Oct;
10(501).
PMID: 29042482
The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties. We found that at high concentrations of resveratrol, human CD4 T cells showed...
9.
Yong C, Abba Moussa D, Cretenet G, Kinet S, Dardalhon V, Taylor N
FEBS Lett
. 2017 Sep;
591(19):3104-3118.
PMID: 28901530
T cells are stimulated by the engagement of antigen, cytokine, pathogen, and hormone receptors. While research performed over many years has focused on deciphering the molecular components of these pathways,...
10.
Cretenet G, Clerc I, Matias M, Loisel S, Craveiro M, Oburoglu L, et al.
Sci Rep
. 2016 Apr;
6:24129.
PMID: 27067254
CD4 and CD8 T lymphocyte activation requires the generation of sufficient energy to support new biosynthetic demands. Following T cell receptor (TCR) engagement, these requirements are met by an increased...