Gary C Pien
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Explore the profile of Gary C Pien including associated specialties, affiliations and a list of published articles.
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9
Citations
635
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Recent Articles
1.
Hui D, Edmonson S, Podsakoff G, Pien G, Ivanciu L, Camire R, et al.
Mol Ther Methods Clin Dev
. 2015 Oct;
2:15029.
PMID: 26445723
Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market...
2.
Hui D, Basner-Tschakarjan E, Chen Y, Davidson R, Buchlis G, Yazicioglu M, et al.
Mol Ther
. 2013 Jul;
21(9):1727-37.
PMID: 23857231
Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed...
3.
Pien G, LeBenger K, Carotenuto D, Difilippi M, Scolpino D, Simmons J, et al.
Allergy Asthma Proc
. 2010 Oct;
31(6):507-10.
PMID: 20943012
Egg allergy is a contraindication for influenza vaccination because of the presence of trace egg protein. Although recent reports suggest that egg-allergic individuals can be safely immunized with seasonal influenza...
4.
Finn J, Hui D, Downey H, Dunn D, Pien G, Mingozzi F, et al.
Mol Ther
. 2009 Nov;
18(1):135-42.
PMID: 19904235
Adeno-associated viral (AAV) vectors are an extensively studied and highly used vector platform for gene therapy applications. We hypothesize that in the first clinical trial using AAV to treat hemophilia...
5.
Pien G, Basner-Tschakarjan E, Hui D, Mentlik A, Finn J, Hasbrouck N, et al.
J Clin Invest
. 2009 May;
119(6):1688-95.
PMID: 19436115
Adeno-associated virus (AAV) vectors are effective gene delivery vehicles mediating long-lasting transgene expression. Data from a clinical trial of AAV2-mediated hepatic transfer of the Factor IX gene (F9) into hemophilia...
6.
Pien G, Orange J
Ann Allergy Asthma Immunol
. 2008 May;
100(4):392-5.
PMID: 18450128
Increases in total serum IgE levels can be observed in many diverse conditions, from infection to atopy to primary immunodeficiency. The differentiation of atopy from immunodeficiency most often is made...
7.
Huang D, Shi F, Jung S, Pien G, Wang J, Salazar-Mather T, et al.
FASEB J
. 2006 May;
20(7):896-905.
PMID: 16675847
Leukocyte trafficking to the central nervous system (CNS), regulated in part by chemokines, determines severity of the demyelinating diseases multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). To examine chemokine...
8.
Pien G, Nguyen K, Malmgaard L, Satoskar A, Biron C
J Immunol
. 2002 Nov;
169(10):5827-37.
PMID: 12421964
The kinetics of CD8 T cell IFN-gamma responses as they occur in situ are defined here during lymphocytic choriomeningitis virus (LCMV) infections, and a unique mechanism for the innate cytokines...
9.
Nguyen K, Watford W, Salomon R, Hofmann S, Pien G, Morinobu A, et al.
Science
. 2002 Sep;
297(5589):2063-6.
PMID: 12242445
Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1 IFNs IFN-alpha and IFN-beta (IFN-alpha/beta) have been established, their immunoregulatory functions, especially their ability to...