Gaochan Wu
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Explore the profile of Gaochan Wu including associated specialties, affiliations and a list of published articles.
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23
Citations
304
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Recent Articles
1.
Jing L, Wu G, Zhao F, Jiang X, Liu N, Feng D, et al.
Eur J Med Chem
. 2024 Aug;
277:116772.
PMID: 39167895
In addressing the urgent need for novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) to combat drug resistance, we employed CuAAC click chemistry to construct a diverse 312-member diarylpyrimidine (DAPY) derivative...
2.
Jing L, Wei W, Meng B, Chantegreil F, Nachon F, Martinez A, et al.
Bioorg Chem
. 2023 Mar;
134:106465.
PMID: 36933339
Butyrylcholinesterase is regarded as a promising drug target in advanced Alzheimer's disease. In order to identify highly selective and potent BuChE inhibitors, a 53-membered compound library was constructed via the...
3.
Tao Y, Hao X, Jing L, Sun L, Cherukupalli S, Liu S, et al.
Bioorg Chem
. 2021 Aug;
115:105254.
PMID: 34426152
Cell division cycle 25 (Cdc25) phosphatase is an attractive target for drug discovery. The rapid assembly and in situ screening of focused combinatorial fragment libraries using efficient modular reactions is...
4.
Kang D, Feng D, Jing L, Sun Y, Wei F, Jiang X, et al.
Eur J Med Chem
. 2020 Mar;
193:112237.
PMID: 32200201
HIV-1 RT has been considered as one of the most important targets for the development of anti-HIV-1 drugs for their well-solved three-dimensional structure and well-known mechanism of action. In this...
5.
Jiang X, Wu G, Zalloum W, Meuser M, Dick A, Sun L, et al.
RSC Adv
. 2020 Feb;
9(50):28961-28986.
PMID: 32089839
The HIV-1 capsid (CA) protein plays crucial roles in both early and late stages of the viral life cycle, which has intrigued researchers to target it to develop anti-HIV drugs....
6.
Jing L, Wu G, Hao X, Olotu F, Kang D, Chen C, et al.
Eur J Med Chem
. 2019 Sep;
183:111696.
PMID: 31541869
Cell division cycle 25 (Cdc25) protein phosphatases play key roles in the transition between the cell cycle phases and their association with various cancers has been widely proven, which makes...
7.
Jiang X, Hao X, Jing L, Wu G, Kang D, Liu X, et al.
Expert Opin Drug Discov
. 2019 May;
14(8):779-789.
PMID: 31094231
: Click chemistry has been exploited widely in the past to expedite lead discovery and optimization. Indeed, Copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry is a bioorthogonal reaction of widespread utility...
8.
Wu G, Zhao T, Kang D, Zhang J, Song Y, Namasivayam V, et al.
J Med Chem
. 2019 May;
62(21):9375-9414.
PMID: 31050421
Introducing novel strategies, concepts, and technologies that speed up drug discovery and the drug development cycle is of great importance both in the highly competitive pharmaceutical industry as well as...
9.
Zhou Z, Liu T, Wu G, Kang D, Fu Z, Wang Z, et al.
Org Biomol Chem
. 2019 Mar;
17(12):3202-3217.
PMID: 30839042
Enlightened by our previous efforts to modify diarylpyrimidines as HIV-1 non-nucleoside reverse transcriptase (RT) inhibitors (NNRTIs) and the reported crystallographic studies, we designed and synthesized novel 1,2,3-triazole-derived diarylpyrimidine derivatives via...
10.
Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque F, et al.
J Med Chem
. 2019 Jan;
62(3):1484-1501.
PMID: 30624934
To address drug resistance to HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs), a series of novel diarylpyrimidine (DAPY) derivatives targeting "tolerant region I" and "tolerant region II" of the NNRTIs binding...