Gail Fraizer
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Explore the profile of Gail Fraizer including associated specialties, affiliations and a list of published articles.
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11
Citations
193
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Recent Articles
1.
Plonski N, Johnson E, Frederick M, Mercer H, Fraizer G, Meindl R, et al.
BMC Bioinformatics
. 2020 Dec;
21(Suppl 18):578.
PMID: 33375933
Background: As the number of RNA-seq datasets that become available to explore transcriptome diversity increases, so does the need for easy-to-use comprehensive computational workflows. Many available tools facilitate analyses of...
2.
Eisermann K, Fraizer G
Cancers (Basel)
. 2017 Apr;
9(4).
PMID: 28394264
Prostate cancer progression is controlled by the androgen receptor and new blood vessel formation, or angiogenesis, which promotes metastatic prostate cancer growth. Angiogenesis is induced by elevated expression of vascular...
3.
Brett A, Pandey S, Fraizer G
Mol Cancer
. 2013 Jan;
12:3.
PMID: 23298185
Background: One key step in the development of prostate cancer (PCa) metastasis is the loss of E-cadherin expression associated with increased cellular motility and tumor invasion. This loss of E-cadherin...
4.
Gregg J, Fraizer G
Genes Cancer
. 2012 May;
2(9):900-9.
PMID: 22593802
The early growth response gene 1, EGR1, is an important transcriptional regulator and acts as the convergent point between a variety of extracellular stimuli and activation of target genes. Unlike...
5.
Joshi B, Chakrabarty A, Bruot C, Ainsworth H, Fraizer G, Wei Q
Anal Bioanal Chem
. 2010 Jan;
396(4):1415-21.
PMID: 20063154
Interactions of proteins with DNA play an important role in regulating the biological functions of DNA. Here we propose and demonstrate the detection of protein-DNA binding using surface-enhanced Raman scattering...
6.
Eisermann K, Tandon S, Bazarov A, Brett A, Fraizer G, Piontkivska H
BMC Genomics
. 2008 Jul;
9:337.
PMID: 18631392
Background: Gene expression analyses have led to a better understanding of growth control of prostate cancer cells. We and others have identified the presence of several zinc finger transcription factors...
7.
Cash J, Korchnak A, Gorman J, Tandon Y, Fraizer G
Oncol Rep
. 2007 May;
17(6):1413-9.
PMID: 17487399
To identify physiologically relevant WT1 transcriptional target genes in prostate cancer cells, we have established stably transfected LNCaP cell lines expressing either WT1(A), its mutant counterpart DDS(R384W), or vector control....
8.
Hanson J, Gorman J, Reese J, Fraizer G
Front Biosci
. 2006 Nov;
12:2279-90.
PMID: 17127464
Understanding angiogenesis and growth control is central for elucidating prostate tumorigenesis. However, the mechanisms of activation of the angiogenic gene, vascular endothelial growth factor (VEGF) are complex and its regulation...
9.
Hanson J, Reese J, Gorman J, Cash J, Fraizer G
Front Biosci
. 2006 Nov;
12:1387-94.
PMID: 17127389
The zinc finger transcription factor, WT1, regulates many growth control genes, repressing or activating transcription depending on the gene and cell type. Based on earlier analyses of the effect of...
10.
Graham K, Li W, Williams B, Fraizer G
Gene Expr
. 2006 Apr;
13(1):1-14.
PMID: 16572586
The Wilms' tumor suppressor gene product (WT1) regulates expression of growth control genes. Microarray analysis of gene expression profiles of hormone-treated LNCaP prostate cancer cell lines transfected with either wild-type...