Kurtis Eisermann
Overview
Explore the profile of Kurtis Eisermann including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
245
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0
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Recent Articles
1.
Masoodi K, Eisermann K, Yang Z, Dar J, Pascal L, Nguyen M, et al.
Endocrinology
. 2017 Oct;
158(10):3152-3161.
PMID: 28977599
The androgen receptor (AR) plays a critical role in the development of castration-resistant prostate cancer (CRPC) as well as in the resistance to the second-generation AR antagonist enzalutamide and the...
2.
Masoodi K, Xu Y, Dar J, Eisermann K, Pascal L, Parrinello E, et al.
Mol Cancer Ther
. 2017 Jun;
16(10):2120-2129.
PMID: 28655783
The androgen receptor (AR) is a ligand-dependent transcription factor that controls the expression of androgen-responsive genes. A key step in androgen action, which is amplified in castration-resistant prostate cancer (CRPC),...
3.
Eisermann K, Fraizer G
Cancers (Basel)
. 2017 Apr;
9(4).
PMID: 28394264
Prostate cancer progression is controlled by the androgen receptor and new blood vessel formation, or angiogenesis, which promotes metastatic prostate cancer growth. Angiogenesis is induced by elevated expression of vascular...
4.
Johnson J, Skoda E, Zhou J, Parrinello E, Wang D, OMalley K, et al.
ACS Med Chem Lett
. 2016 Aug;
7(8):785-90.
PMID: 27563404
After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure-activity relationship (SAR) purposes and analogues were synthesized...
5.
Eisermann K, Dar J, Dong J, Wang D, Masoodi K, Wang Z
PLoS One
. 2015 Jul;
10(7):e0128495.
PMID: 26176602
The androgen receptor (AR) is a member of the steroid receptor superfamily that regulates gene expression in a ligand-dependent manner. The NTD of the AR plays a key role in...
6.
Eisermann K, Wang D, Jing Y, Pascal L, Wang Z
Transl Androl Urol
. 2014 Jul;
2(3):137-147.
PMID: 25045626
Genetic aberrations of the androgen receptor (AR) caused by mutations, rearrangements, and polymorphisms result in a mutant receptor that has varied functions compared to wild type AR. To date, over...
7.
OMalley K, Eisermann K, Pascal L, Parwani A, Majima T, Graham L, et al.
Prostate
. 2014 Apr;
74(8):892-900.
PMID: 24711254
Background: Benign prostatic hyperplasia (BPH) is an age-related disease frequently associated with lower urinary tract symptoms (LUTS) that involves hyperplasia of both epithelial and stromal cells. Stromal fibrosis is a...
8.
Dar J, Masoodi K, Eisermann K, Isharwal S, Ai J, Pascal L, et al.
J Steroid Biochem Mol Biol
. 2014 Mar;
143:473-80.
PMID: 24662325
Androgen-independent nuclear localization is required for androgen receptor (AR) transactivation in castration-resistant prostate cancer (CRPC) and should be a key step leading to castration resistance. However, mechanism(s) leading to androgen-independent...
9.
Pascal L, Ai J, Masoodi K, Wang Y, Wang D, Eisermann K, et al.
PLoS One
. 2013 Nov;
8(11):e79542.
PMID: 24260246
ELL-associated factor 2 (EAF2) is an androgen-responsive tumor suppressor frequently deleted in advanced prostate cancer that functions as a transcription elongation factor of RNA Pol II through interaction with the...
10.
Dar J, Eisermann K, Masoodi K, Ai J, Wang D, Severance T, et al.
J Steroid Biochem Mol Biol
. 2013 Oct;
139:16-24.
PMID: 24099702
Nucleocytoplasmic trafficking of the androgen receptor (AR) represents an essential step in androgen action. To determine whether the amino-terminal domain (NTD) contains potential nuclear import and/or export signals, deletion mutants...