Gagandeep Narula
Overview
Explore the profile of Gagandeep Narula including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
140
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0
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Recent Articles
1.
Tsui C, Sorrentino F, Narula G, Mendoza-Losana A, Gonzalez Del Rio R, Perez Herran E, et al.
Molecules
. 2022 Jul;
27(14).
PMID: 35889319
(), the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Chemical-genetic characterization through in vitro evolution combined with whole genome sequencing analysis was...
2.
Richter A, Narula G, Rudolph I, Seidel R, Wagner C, Av-Gay Y, et al.
ChemMedChem
. 2021 Dec;
17(6):e202100733.
PMID: 34939744
8-Nitrobenzothiazinones (BTZs) are a promising class of antimycobacterial agents currently under investigation in clinical trials. Starting from thiourea derivatives, a new synthetic pathway to BTZs was established. It allows the...
3.
Moure A, Narula G, Sorrentino F, Bojang A, Tsui C, Emani C, et al.
J Med Chem
. 2020 Apr;
63(9):4732-4748.
PMID: 32275415
Screening of a GSK-proprietary library against intracellular identified , a thioalkylbenzoxazole hit. Biological profiling and mutant analysis revealed that this compound is a prodrug that is bioactivated by the mycobacterial...
4.
Wong D, Li W, Chao J, Zhou P, Narula G, Tsui C, et al.
Sci Rep
. 2018 Jan;
8(1):155.
PMID: 29317718
Protein phosphorylation plays a key role in Mycobacterium tuberculosis (Mtb) physiology and pathogenesis. We have previously shown that a secreted protein tyrosine phosphatase, PtpA, is essential for Mtb inhibition of...
5.
Tsui C, Wong D, Narula G, Gardy J, Hsiao W, Av-Gay Y
Genome Announc
. 2017 Nov;
5(44).
PMID: 29097456
, the etiological agent of tuberculosis, is one of the most devastating infectious agents in the world. Here, we report the draft genome sequences of the protein tyrosine kinase ()...
6.
Williams D, Dalisay D, Chen J, Polishchuck E, Patrick B, Narula G, et al.
Org Lett
. 2017 Feb;
19(4):766-769.
PMID: 28164711
The new ansa macrolide antibiotics 1 to 4 have been isolated from cultures of a Micromonospora sp. obtained from a marine sediment. Rifamycins 1 and 2 are the first natural...
7.
Yu X, Zhang M, Annamalai T, Bansod P, Narula G, Tse-Dinh Y, et al.
Eur J Med Chem
. 2016 Oct;
125:515-527.
PMID: 27689733
New antibacterial agents with novel target and mechanism of action are urgently needed to combat problematic bacterial infections and mounting antibiotic resistances. Topoisomerase IA represents an attractive and underexplored antibacterial...
8.
Sandhaus S, Annamalai T, Welmaker G, Houghten R, Paz C, Garcia P, et al.
Antimicrob Agents Chemother
. 2016 Apr;
60(7):4028-36.
PMID: 27114277
Bacterial topoisomerase functions are required for regulation of DNA supercoiling and overcoming the DNA topological barriers that are encountered during many vital cellular processes. DNA gyrase and topoisomerase IV of...
9.
Feng L, Maddox M, Alam M, Tsutsumi L, Narula G, Bruhn D, et al.
J Med Chem
. 2014 Sep;
57(20):8398-420.
PMID: 25238443
On the basis of recently reported abyssinone II and olympicin A, a series of chemically modified flavonoid phytochemicals were synthesized and evaluated against Mycobacterium tuberculosis and a panel of Gram-positive...
10.
Tiwari P, Annamalai T, Cheng B, Narula G, Wang X, Tse-Dinh Y, et al.
Biochem Biophys Res Commun
. 2014 Feb;
445(2):445-50.
PMID: 24530905
To date, the bacterial DNA topoisomerases are one of the major target biomolecules for the discovery of new antibacterial drugs. DNA topoisomerase regulates the topological state of DNA, which is...