Gad Frankel
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Explore the profile of Gad Frankel including associated specialties, affiliations and a list of published articles.
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237
Citations
8469
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Recent Articles
1.
Herzog M, Peters A, Shayya N, Cazzaniga M, Kaka Bra K, Arora T, et al.
Gut Microbes
. 2025 Jan;
17(1):2447832.
PMID: 39835346
, non-typhoidal spp., and enteropathogenic/enterohemorrhagic (EPEC/EHEC) are leading causes of food-borne illness worldwide. has been used to model EPEC and EHEC infection in mice. The gut microbiome is well-known to...
2.
Seddon C, David S, Wong J, Ishimoto N, He S, Bradshaw J, et al.
Nat Commun
. 2025 Jan;
16(1):659.
PMID: 39809778
Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractory to a second wave of conjugation with the same plasmid via...
3.
Ishimoto N, Wong J, Singh N, Shirran S, He S, Seddon C, et al.
bioRxiv
. 2025 Jan;
PMID: 39803431
Conjugation, the major driver of the spread of antimicrobial resistance genes, relies on a conjugation pilus for DNA transfer. Conjugative pili, such as the F-pilus, are dynamic tubular structures, composed...
4.
Sanchez-Garrido J, Baghshomali Y, Kaushal P, Kozik Z, Perry R, Williams H, et al.
Mucosal Immunol
. 2024 Jun;
17(5):939-957.
PMID: 38936619
Citrobacter rodentium models infection with enteropathogenic Escherichia coli and ulcerative colitis (UC). While C57BL/6 (C57) mice recover, C3H/HeN (C3H) mice succumb to infection, partially due to increased colonic neutrophil elastase...
5.
Vieira M, Hernandez G, Zhong Q, Arbesu M, Veloso T, Gomes T, et al.
Commun Biol
. 2024 Feb;
7(1):179.
PMID: 38351154
The translocated intimin receptor (Tir) is an essential type III secretion system (T3SS) effector of attaching and effacing pathogens contributing to the global foodborne disease burden. Tir acts as a...
6.
Seddon C, Frankel G, Beis K
Acta Crystallogr F Struct Biol Commun
. 2024 Jan;
80(Pt 1):22-27.
PMID: 38206593
Conjugation is the process by which plasmids, including those that carry antibiotic-resistance genes, are mobilized from one bacterium (the donor) to another (the recipient). The conjugation efficiency of IncF-like plasmids...
7.
Di Pilato V, Codda G, Niccolai C, Willison E, Wong J, Coppo E, et al.
Int J Antimicrob Agents
. 2023 Nov;
63(1):107030.
PMID: 37931849
Objectives: To investigate a ceftazidime/avibactam (CZA)-resistant Klebsiella pneumoniae (NE368), isolated from a patient exposed to CZA, expressing a novel K. pneumoniae carbapenemase (KPC)-3 variant (KPC-109). Methods: Antimicrobial susceptibility testing was...
8.
Frankel G, David S, Low W, Seddon C, Wong J, Beis K
Nucleic Acids Res
. 2023 Aug;
51(17):8925-8933.
PMID: 37592747
Bacterial conjugation was first described by Lederberg and Tatum in the 1940s following the discovery of the F plasmid. During conjugation a plasmid is transferred unidirectionally from one bacterium (the...
9.
Wiggins B, Wang Y, Burke A, Grunberg N, Vlachaki Walker J, Dore M, et al.
Nature
. 2023 Aug;
621(7980):821-829.
PMID: 37586410
Endothelial cells line the blood and lymphatic vasculature, and act as an essential physical barrier, control nutrient transport, facilitate tissue immunosurveillance and coordinate angiogenesis and lymphangiogenesis. In the intestine, dietary...
10.
Wong J, Romano M, Kerry L, Kwong H, Low W, Brett S, et al.
Nat Commun
. 2023 Apr;
14(1):1934.
PMID: 37024486
No abstract available.