Gabrielle E Giese
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Explore the profile of Gabrielle E Giese including associated specialties, affiliations and a list of published articles.
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9
Citations
171
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Recent Articles
1.
Zhang H, Li X, Tseyang L, Giese G, Wang H, Yao B, et al.
Nature
. 2025 Feb;
PMID: 40011784
Metabolic flux, or the rate of metabolic reactions, is one of the most fundamental metrics describing the status of metabolism in living organisms. However, measuring fluxes across the entire metabolic...
2.
Ponomarova O, Zhang H, Li X, Nanda S, Leland T, Fox B, et al.
PLoS Biol
. 2023 Apr;
21(4):e3002057.
PMID: 37043428
In humans, mutations in D-2-hydroxyglutarate (D-2HG) dehydrogenase (D2HGDH) result in D-2HG accumulation, delayed development, seizures, and ataxia. While the mechanisms of 2HG-associated diseases have been studied extensively, the endogenous metabolism...
3.
Bhattacharya S, Horowitz B, Zhang J, Li X, Zhang H, Giese G, et al.
iScience
. 2022 Jul;
25(8):104688.
PMID: 35847555
Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations...
4.
Fox B, Ponomarova O, Lee Y, Zhang G, Giese G, Walker M, et al.
Nature
. 2022 Jul;
607(7919):571-577.
PMID: 35794472
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic background, nutritional input, microbiota and other environmental factors. It is difficult to connect differences in metabolism...
5.
Walker M, Giese G, Holdorf A, Bhattacharya S, Diot C, Garcia-Gonzalez A, et al.
Genetics
. 2021 Jun;
219(1).
PMID: 34117752
In our group, we aim to understand metabolism in the nematode Caenorhabditis elegans and its relationships with gene expression, physiology, and the response to therapeutic drugs. Visualization of the metabolic...
6.
Walker M, Giese G, Holdorf A, Bhattacharya S, Diot C, Garcia-Gonzalez A, et al.
bioRxiv
. 2021 Jan;
PMID: 33398287
In our group, we aim to understand metabolism in the nematode and its relationships with gene expression, physiology and the response to therapeutic drugs. On March 15, 2020, a stay-at-home...
7.
Giese G, Walker M, Ponomarova O, Zhang H, Li X, Minevich G, et al.
Elife
. 2020 Oct;
9.
PMID: 33016879
Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle. In low vitamin B12, or genetic perturbation of...
8.
Bulcha J, Giese G, Ali M, Lee Y, Walker M, Holdorf A, et al.
Cell Rep
. 2019 Jan;
26(2):460-468.e4.
PMID: 30625328
Biological systems must possess mechanisms that prevent inappropriate responses to spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the short-chain fatty acid propionate: a canonical, vitamin B12-dependent pathway...
9.
Na H, Ponomarova O, Giese G, Walhout A
Cell Rep
. 2018 Mar;
22(12):3126-3133.
PMID: 29562169
Vitamin B12 functions as a cofactor for methionine synthase to produce the anabolic methyl donor S-adenosylmethionine (SAM) and for methylmalonyl-CoA mutase to catabolize the short-chain fatty acid propionate. In the...
10.
MacNeil L, Pons C, Arda H, Giese G, Myers C, Walhout A
Cell Syst
. 2015 Oct;
1(2):152-162.
PMID: 26430702
A wealth of physical interaction data between transcription factors (TFs) and DNA has been generated, but these interactions often do not have apparent regulatory consequences. Thus, equating physical interaction data...