Albertha J M Walhout
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Explore the profile of Albertha J M Walhout including associated specialties, affiliations and a list of published articles.
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109
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6011
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Recent Articles
1.
Li X, Zhang H, Hodder T, Wang W, Myers C, Yilmaz L, et al.
Nature
. 2025 Feb;
PMID: 40011787
The regulation of metabolism is vital to any organism and can be achieved by transcriptionally activating or repressing metabolic genes. Although many examples of transcriptional metabolic rewiring have been reported,...
2.
Zhang H, Li X, Tseyang L, Giese G, Wang H, Yao B, et al.
Nature
. 2025 Feb;
PMID: 40011784
Metabolic flux, or the rate of metabolic reactions, is one of the most fundamental metrics describing the status of metabolism in living organisms. However, measuring fluxes across the entire metabolic...
3.
Zhang H, Li X, Song D, Yukselen O, Nanda S, Kucukural A, et al.
bioRxiv
. 2025 Feb;
PMID: 39975282
The transcriptome provides a highly informative molecular phenotype to connect genotype to phenotype and is most frequently measured by RNA-sequencing (RNA-seq). Therefore, an ultimate goal is to perturb every gene...
4.
Li X, Walhout A, Yilmaz L
Mol Syst Biol
. 2025 Feb;
PMID: 39962320
Algorithms that constrain metabolic network models with enzyme levels to predict metabolic activity assume that changes in enzyme levels are indicative of flux variations. However, metabolic flux can also be...
5.
Lee Y, Fox B, Guo R, Curtis B, Yu J, Kim S, et al.
Nat Metab
. 2024 Aug;
6(9):1837.
PMID: 39147935
No abstract available.
6.
Lee Y, Fox B, Guo R, Curtis B, Yu J, Kim S, et al.
Nat Metab
. 2024 Aug;
6(8):1584-1600.
PMID: 39117959
In humans, defects in leucine catabolism cause a variety of inborn errors in metabolism. Here, we use Caenorhabditis elegans to investigate the impact of mutations in mccc-1, an enzyme that...
7.
Ponomarova O, Starbard A, Belfi A, Anderson A, Sundaram M, Walhout A
bioRxiv
. 2024 Apr;
PMID: 38559246
The isocitrate dehydrogenase neomorphic mutation ( ) generates increased levels of cellular D-2-hydroxyglutarate (D-2HG), a proposed oncometabolite. However, the physiological effects of increased D-2HG and whether additional metabolic changes occur...
8.
Kang W, Florman J, Araya A, Fox B, Thackeray A, Schroeder F, et al.
Nat Cell Biol
. 2024 Jan;
26(1):72-85.
PMID: 38168768
A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown....
9.
Doshi M, Lee N, Tseyang T, Ponomarova O, Goel H, Spears M, et al.
Nature
. 2023 Oct;
623(7987):625-632.
PMID: 37880368
Identifying metabolic steps that are specifically required for the survival of cancer cells but are dispensable in normal cells remains a challenge. Here we report a therapeutic vulnerability in a...
10.
Mirza Z, Walhout A, Ambros V
Cell Rep
. 2023 Oct;
42(10):113189.
PMID: 37801396
Host-pathogen interactions are complex by nature, and the host developmental stage increases this complexity. By utilizing Caenorhabditis elegans larvae as the host and the bacterium Pseudomonas aeruginosa as the pathogen,...