Gabriella De Angelis
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Explore the profile of Gabriella De Angelis including associated specialties, affiliations and a list of published articles.
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10
Citations
193
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Recent Articles
1.
Biolchi A, De Angelis G, Moschioni M, Tomei S, Brunelli B, Giuliani M, et al.
Vaccine
. 2020 Oct;
38(47):7542-7550.
PMID: 33036804
Background: The multicomponent meningococcal serogroup B vaccine (4CMenB) is currently indicated for active immunization against invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB). However, genes encoding the 4CMenB...
2.
Biagini M, Spinsanti M, De Angelis G, Tomei S, Ferlenghi I, Scarselli M, et al.
Proc Natl Acad Sci U S A
. 2016 Feb;
113(10):2714-9.
PMID: 26888286
Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the survival of the bacterium in human blood and a component of two recently licensed vaccines against...
3.
Amerighi F, Valeri M, Donnarumma D, Maccari S, Moschioni M, Taddei A, et al.
J Infect Dis
. 2015 Sep;
213(4):516-22.
PMID: 26401026
The adhesion of Streptococcus pneumoniae is a key step during colonization of human respiratory tract mucosae. Here we demonstrate that pneumococcal type I pilus significantly increases the adhesiveness of poorly...
4.
Giufre M, De Chiara M, Censini S, Guidotti S, Torricelli G, De Angelis G, et al.
Genome Announc
. 2015 Mar;
3(2).
PMID: 25814593
Haemophilus influenzae is an important human pathogen involved in invasive disease. Here, we report the whole-genome sequences of 11 nonencapsulated H. influenzae (ncHi) strains isolated from both invasive disease and...
5.
Gasparini R, Comanducci M, Amicizia D, Ansaldi F, Canepa P, Orsi A, et al.
J Clin Microbiol
. 2014 Mar;
52(6):1901-10.
PMID: 24648565
Neisseria meningitidis is an obligate human commensal that commonly colonizes the oropharyngeal mucosa. Carriage is age dependent and very common in young adults. The relationships between carriage and invasive disease...
6.
Figueira M, Moschioni M, De Angelis G, Barocchi M, Sabharwal V, Masignani V, et al.
PLoS One
. 2014 Jan;
9(1):e83798.
PMID: 24421906
Unlabelled: The pneumococcal Pilus-1 enhances attachment to epithelial cells in the respiratory tract and subsequent invasion. Pilus-1 expression is bi-stable and positively regulated by the RlrA transcriptional regulator. To delineate...
7.
Pancotto L, De Angelis G, Bizzarri E, Barocchi M, Del Giudice G, Moschioni M, et al.
Sci Rep
. 2013 Jun;
3:2040.
PMID: 23784148
Streptococcus pneumoniae pili contribute to adherence and virulence. The regulation of pilus-1 expression is bistable, thus piliated strains contain a variable proportion of pilus-1-non-expressing bacteria. We investigated whether such proportion...
8.
Moschioni M, De Angelis G, Harfouche C, Bizzarri E, Filippini S, Mori E, et al.
Vaccine
. 2012 Jan;
30(7):1349-56.
PMID: 22210141
RrgB321, a fusion protein of the three Streptococcus pneumoniae pilus-1 backbone RrgB variants, is protective in vivo against pilus islet 1 (PI-1) positive pneumococci. In addition, antibodies to RrgB321 mediate...
9.
De Angelis G, Moschioni M, Muzzi A, Pezzicoli A, Censini S, Delany I, et al.
PLoS One
. 2011 Jul;
6(6):e21269.
PMID: 21731688
The Streptococcus pneumoniae pilus-1 is encoded by pilus islet 1 (PI-1), which has three clonal variants (clade I, II and III) and is present in about 30% of clinical pneumococcal...
10.
Hilleringmann M, Ringler P, Muller S, De Angelis G, Rappuoli R, Ferlenghi I, et al.
EMBO J
. 2009 Nov;
28(24):3921-30.
PMID: 19942854
Although the pili of Gram-positive bacteria are putative virulence factors, little is known about their structure. Here we describe the molecular architecture of pilus-1 of Streptococcus pneumoniae, which is a...