Gabriel Frampton
Overview
Explore the profile of Gabriel Frampton including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
910
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0
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Recent Articles
1.
Jhawer A, Frampton G, Bhattarai S, DeMorrow S, McMillin M
Metab Brain Dis
. 2024 Dec;
40(1):57.
PMID: 39656327
Acute liver failure results from severe hepatic injury and can lead to neurological dysfunction known as hepatic encephalopathy (HE). Thrombospondin-1 can contribute to HE by increasing cerebral edema and microglia...
2.
Shipley A, Frampton G, Davies B, Umlauf B
Front Oncol
. 2023 Dec;
13:1229747.
PMID: 38074687
Introduction: The use of microorganisms as drug delivery systems to treat cancer has expanded recently, including FDA approval of certain viruses as oncolytics. Microorganisms have several unique benefits compared to...
3.
Umlauf B, Frampton G, Cooper A, Greene H
J Control Release
. 2023 Oct;
364:195-205.
PMID: 37865172
Patients with glioblastoma (GBM) face a poor prognosis with a median survival of less than two years. Escalating the dose of chemotherapy is often impossible due to patient comorbidities; thus,...
4.
Petrescu A, Grant S, Williams E, An S, Seth N, Shell M, et al.
Am J Pathol
. 2021 Dec;
192(3):484-502.
PMID: 34896073
Leptin is an adipokine with roles in food intake and energy metabolism through its actions on neurons in the hypothalamus. The role of leptin in obesity and cardiovascular disorders is...
5.
Frampton G, Reddy P, Jefferson B, Ali M, Khan D, McMillin M
Toxicol Appl Pharmacol
. 2020 Nov;
409:115323.
PMID: 33176120
Acetaminophen (N-Acetyl-p-Aminophenol or APAP)-induced hepatotoxicity is the most common cause of acute liver failure in the United States and Western Europe. Previous studies have shown that TGFβ1 is elevated during...
6.
Petrescu A, Grant S, Williams E, Frampton G, Reinhart E, Nguyen A, et al.
Sci Rep
. 2020 Sep;
10(1):16024.
PMID: 32994489
The orexigenic peptide ghrelin (Ghr) stimulates hunger signals in the hypothalamus via growth hormone secretagogue receptor (GHS-R1a). Gastric Ghr is synthetized as a preprohormone which is proteolytically cleaved, and acylated...
7.
Petrescu A, Grant S, Williams E, Frampton G, Parks N, Blaney H, et al.
Am J Pathol
. 2020 Jan;
190(3):586-601.
PMID: 31953035
Galanin (Gal) is a peptide with a role in neuroendocrine regulation of the liver. In this study, we assessed the role of Gal and its receptors, Gal receptor 1 (GalR1)...
8.
Jefferson B, Ali M, Grant S, Frampton G, Ploof M, Andry S, et al.
Am J Pathol
. 2019 Nov;
190(2):347-357.
PMID: 31734229
Severe hepatic insults can lead to acute liver failure and hepatic encephalopathy (HE). Transforming growth factor β1 (TGFβ1) has been shown to contribute to HE during acute liver failure; however,...
9.
McMillin M, Grant S, Frampton G, Petrescu A, Williams E, Jefferson B, et al.
Toxicol Sci
. 2019 May;
170(2):549-561.
PMID: 31132129
Acute liver failure is a serious consequence of acetaminophen (APAP)-induced hepatotoxic liver injury with high rates of morbidity and mortality. Transforming growth factor beta 1 (TGFβ1) is elevated during liver...
10.
McMillin M, Grant S, Frampton G, Petrescu A, Williams E, Jefferson B, et al.
J Neuroinflammation
. 2019 Apr;
16(1):69.
PMID: 30940161
Background: Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated...