Gabriel Frampton
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Explore the profile of Gabriel Frampton including associated specialties, affiliations and a list of published articles.
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36
Citations
910
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Recent Articles
11.
Petrescu A, Grant S, Frampton G, McMillin M, Kain J, Kodali M, et al.
Sci Rep
. 2018 Sep;
8(1):13147.
PMID: 30177688
Gulf War Illness (GWI) is a chronic multisymptom disorder affecting veterans of the 1990-91 Gulf war. GWI was linked with exposure to chemicals including the nerve gas prophylactic drug pyridostigmine-bromide...
12.
McMillin M, Grant S, Frampton G, Petrescu A, Kain J, Williams E, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Jun;
6(1):47-63.
PMID: 29928671
Background & Aims: Hepatic encephalopathy is a serious neurologic complication of acute and chronic liver diseases. We previously showed that aberrant bile acid signaling contributes to the development of hepatic...
13.
Grant S, McMillin M, Frampton G, Petrescu A, Williams E, Jaeger V, et al.
Gene Expr
. 2018 Jun;
18(3):171-185.
PMID: 29895352
Acute liver failure is a devastating consequence of hepatotoxic liver injury that can lead to the development of hepatic encephalopathy. There is no consensus on the best model to represent...
14.
Glucocorticoids Cause Gender-Dependent Reversal of Hepatic Fibrosis in the MDR2-Knockout Mouse Model
Petrescu A, Grant S, Frampton G, Kain J, Hadidi K, Williams E, et al.
Int J Mol Sci
. 2017 Nov;
18(11).
PMID: 29125588
Hepatic cholestasis is associated with a significant suppression of the hypothalamus-pituitary-adrenal axis (HPA). In the present study, we tested the hypothesis that activation of the HPA axis by corticosterone treatment...
15.
McMillin M, Frampton G, Grant S, Khan S, Diocares J, Petrescu A, et al.
Front Cell Neurosci
. 2017 Jul;
11:191.
PMID: 28725183
Hepatic encephalopathy (HE) is a neuropsychiatric complication that occurs due to deteriorating hepatic function and this syndrome influences patient quality of life, clinical management strategies and survival. During acute liver...
16.
McMillin M, Frampton G, Grant S, DeMorrow S
Am J Pathol
. 2017 Feb;
187(4):819-830.
PMID: 28196718
During the course of cholestatic liver diseases, mitotically dormant cholangiocytes proliferate and subsequently acquire a neuroendocrine phenotype. Galanin is a neuroendocrine factor responsible for regulation of physiological responses, such as...
17.
Nizamutdinov D, DeMorrow S, McMillin M, Kain J, Mukherjee S, Zeitouni S, et al.
Sci Rep
. 2017 Jan;
7:40112.
PMID: 28106051
Annually, there are over 2 million incidents of traumatic brain injury (TBI) and treatment options are non-existent. While many TBI studies have focused on the brain, peripheral contributions involving the...
18.
McMillin M, Grant S, Frampton G, Andry S, Brown A, DeMorrow S
J Neuroinflammation
. 2016 Aug;
13(1):198.
PMID: 27561705
Background: Acute liver failure is associated with numerous systemic consequences including neurological dysfunction, termed hepatic encephalopathy, which contributes to mortality and is a challenge to manage in the clinic. During...
19.
Bile Acid Signaling Is Involved in the Neurological Decline in a Murine Model of Acute Liver Failure
McMillin M, Frampton G, Quinn M, Ashfaq S, de los Santos 3rd M, Grant S, et al.
Am J Pathol
. 2015 Dec;
186(2):312-23.
PMID: 26683664
Hepatic encephalopathy is a serious neurological complication of liver failure. Serum bile acids are elevated after liver damage and may disrupt the blood-brain barrier and enter the brain. Our aim...
20.
Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling
McMillin M, Frampton G, Quinn M, Divan A, Grant S, Patel N, et al.
Mol Endocrinol
. 2015 Oct;
29(12):1720-30.
PMID: 26431088
Suppression of the hypothalamic-pituitary-adrenal (HPA) axis has been shown to occur during cholestatic liver injury. Furthermore, we have demonstrated that in a model of cholestasis, serum bile acids gain entry...