Gabriel Courties
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Explore the profile of Gabriel Courties including associated specialties, affiliations and a list of published articles.
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48
Citations
4933
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Recent Articles
11.
Frodermann V, Rohde D, Courties G, Severe N, Schloss M, Amatullah H, et al.
Nat Med
. 2019 Nov;
25(11):1761-1771.
PMID: 31700184
A sedentary lifestyle, chronic inflammation and leukocytosis increase atherosclerosis; however, it remains unclear whether regular physical activity influences leukocyte production. Here we show that voluntary running decreases hematopoietic activity in...
12.
Severe N, Karabacak N, Gustafsson K, Baryawno N, Courties G, Kfoury Y, et al.
Cell Stem Cell
. 2019 Jul;
25(4):570-583.e7.
PMID: 31279774
Stromal cell populations that maintain hematopoietic stem and progenitor cells (HSPCs) are generally characterized in steady-state conditions. Here, we report a comprehensive atlas of bone marrow stromal cell subpopulations under...
13.
Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss M, et al.
Circ Res
. 2019 Feb;
124(9):1372-1385.
PMID: 30782088
Rationale: After a stroke, patients frequently experience altered systemic immunity resulting in peripheral immunosuppression and higher susceptibility to infections, which is at least partly attributed to lymphopenia. The mechanisms that...
14.
Ammari M, Presumey J, Ponsolles C, Roussignol G, Roubert C, Escriou V, et al.
Theranostics
. 2019 Jan;
8(21):5972-5985.
PMID: 30613275
Monocytes play critical roles in the pathogenesis of arthritis by contributing to the inflammatory response and bone erosion. Among genes involved in regulating monocyte functions, miR-146a negatively regulates the inflammatory...
15.
Kim H, Li R, Ng T, Courties G, Rodell C, Prytyskach M, et al.
ACS Nano
. 2018 Dec;
12(12):12015-12029.
PMID: 30508377
Tumor-associated macrophages (TAMs) are widely implicated in cancer progression, and TAM levels can influence drug responses, particularly to immunotherapy and nanomedicines. However, it has been difficult to quantify total TAM...
16.
Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, et al.
JACC Basic Transl Sci
. 2018 Sep;
1(7):633-643.
PMID: 30167547
PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 days decreased the number of inflammatory...
17.
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, et al.
Nat Neurosci
. 2018 Aug;
21(9):1209-1217.
PMID: 30150661
Innate immune cells recruited to inflammatory sites have short life spans and originate from the marrow, which is distributed throughout the long and flat bones. While bone marrow production and...
18.
Vandoorne K, Rohde D, Kim H, Courties G, Wojtkiewicz G, Honold L, et al.
Circ Res
. 2018 Jul;
123(4):415-427.
PMID: 29980569
Rationale: Inflammatory stress induced by exposure to bacterial lipopolysaccharide causes hematopoietic stem cell expansion in the bone marrow niche, generating a cellular immune response. As an integral component of the...
19.
Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos S, Courties G, et al.
Science
. 2017 Dec;
358(6367).
PMID: 29191879
Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth...
20.
Hulsmans M, Clauss S, Xiao L, Aguirre A, King K, Hanley A, et al.
Cell
. 2017 Apr;
169(3):510-522.e20.
PMID: 28431249
Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse...