Ralph Weissleder
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Explore the profile of Ralph Weissleder including associated specialties, affiliations and a list of published articles.
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832
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54528
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Recent Articles
1.
Hricak H, Mayerhoefer M, Herrmann K, Lewis J, Pomper M, Hess C, et al.
Lancet Oncol
. 2025 Jan;
26(1):e34-e45.
PMID: 39756454
Technological innovations in genomics and related fields have facilitated large sequencing efforts, supported new biological discoveries in cancer, and spawned an era of liquid biopsy biomarkers. Despite these advances, precision...
2.
Quintana J, Jiang F, Kang M, Valladolid Onecha V, Konik A, Qin L, et al.
J Nucl Med
. 2025 Jan;
66(1):91-97.
PMID: 39753366
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically...
3.
Deutsch-Williams R, Schleyer K, Das R, Carrothers J, Kohler R, Vinegoni C, et al.
Bioconjug Chem
. 2024 Dec;
36(1):44-53.
PMID: 39667730
Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein alpha (FAP) are abundant in tumor microenvironments and represent an emerging target for PET cancer imaging. While different quinolone-based small molecule agents have...
4.
Bachoo R, Maher E, Ligon K, Sharpless N, Chan S, You M, et al.
Cancer Cell
. 2024 Dec;
42(12):2124.
PMID: 39663072
No abstract available.
5.
Kartal B, Garris C, Kim H, Kohler R, Carrothers J, Halabi E, et al.
Adv Sci (Weinh)
. 2024 Dec;
12(4):e2410360.
PMID: 39639496
Secreted phosphosprotein 1 (SPP1) tumor-associated macrophages (TAM) are abundant tumor myeloid cells that are immunosuppressive, pro-tumorigenic, and have a highly negative prognostic factor. Despite this, there is a lack of...
6.
Landeros C, Oh J, Weissleder R, Lee H
Sci Rep
. 2024 Oct;
14(1):23600.
PMID: 39384907
Cyclic fluorescence microscopy enables multiple targets to be detected simultaneously. This, in turn, has deepened our understanding of tissue composition, cell-to-cell interactions, and cell signaling. Unfortunately, analysis of these datasets...
7.
Uygun K, Filz von Reiterdank I, Mojoudi M, Bento R, Taggart M, Dinicu A, et al.
Res Sq
. 2024 Sep;
PMID: 39315250
Developing new strategies for local monitoring and delivery of immunosuppression is critical to making allografts safer and more accessible. Ex vivo genetic modification of grafts using machine perfusion presents a...
8.
van Solinge T, Oh J, Abels E, Koch P, Breakefield X, Weissleder R, et al.
Neoplasia
. 2024 Sep;
57:101051.
PMID: 39270598
The interaction between gliomas and the immune system is poorly understood and thus hindering development of effective immunotherapies for glioma patients. The immune response is highly variable during tumor development,...
9.
Quintana J, Carlson J, Scott E, Ng T, Miller M, Weissleder R
Bioconjug Chem
. 2024 Sep;
PMID: 39255972
Positron emission tomography (PET) imaging methods have advanced our understanding of human biology, while targeted radiotherapeutic drug treatments are now routinely used clinically. The field is expected to grow considerably...
10.
Shiau C, Cao J, Gong D, Gregory M, Caldwell N, Yin X, et al.
Nat Genet
. 2024 Sep;
56(11):2466-2478.
PMID: 39227743
In combination with cell-intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods and cell-cell interactions in human...