G Thinakaran
Overview
Explore the profile of G Thinakaran including associated specialties, affiliations and a list of published articles.
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62
Citations
3070
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Recent Articles
1.
Wang Y, Wu Q, Anand B, Karthivashan G, Phukan G, Yang J, et al.
Neuropathol Appl Neurobiol
. 2020 Jul;
46(7):686-706.
PMID: 32716575
Background: Evidence suggests that amyloid β (Aβ) peptides play an important role in the degeneration of neurons during the development of Alzheimer's disease (AD), the prevalent cause of dementia affecting...
2.
Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M, et al.
Mol Cell Biol
. 2018 Mar;
38(11).
PMID: 29530923
Amyloid β (Aβ) peptide, derived from amyloid precursor protein (APP), plays a critical role in the development of Alzheimer's disease. Current evidence indicates that altered levels or subcellular distribution of...
3.
Maulik M, Vergote D, Phukan G, Chung J, Thinakaran G, Kar S
Mol Neurobiol
. 2017 Oct;
55(7):5757-5766.
PMID: 29052144
Amyloid precursor protein (APP) is cleaved by a set of proteases including α-/β-/γ- and recently identified η-secretases, generating C-terminal fragments (CTFs) of varying lengths and amyloid β (Aβ) peptides, which...
4.
Wang Y, MacDonald R, Thinakaran G, Kar S
Mol Neurobiol
. 2016 Mar;
54(4):2636-2658.
PMID: 26993302
The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a multifunctional single transmembrane glycoprotein. Recent studies have advanced our understanding of the structure, ligand-binding properties, and trafficking of the IGF-II/M6P...
5.
Wang Y, Buggia-Prevot V, Zavorka M, Bleackley R, MacDonald R, Thinakaran G, et al.
Mol Cell Biol
. 2015 May;
35(14):2368-84.
PMID: 25939386
Amyloid β (Aβ) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosomal compartments play a critical role in the development of Alzheimer's disease (AD), the most common type of...
6.
Thinakaran G, Doan A
Methods Mol Med
. 2011 Feb;
32:283-96.
PMID: 21318526
Mutations in two related genes, PS1 (1) and PS2 (2,3) located on chromosomes 14 and 1, respectively, account for the majority of early onset cases of familial Alzheimer's disease (FAD)....
7.
Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel K, Thinakaran G, et al.
Glia
. 2010 Jul;
58(11):1267-81.
PMID: 20607864
Niemann-Pick type C (NPC) disease is an autosomal recessive neurodegenerative disorder characterized by intracellular accumulation of cholesterol and glycosphingolipids in many tissues including the brain. The disease is caused by...
8.
Kodam A, Vetrivel K, Thinakaran G, Kar S
Neurobiol Aging
. 2007 Jan;
29(5):724-38.
PMID: 17222950
Nicastrin and presenilin 1 are integral components of the high molecular weight gamma-secretase complexes that regulate proteolytic processing of various type I membrane proteins including amyloid precursor protein and Notch....
9.
Thinakaran G
J Mol Neurosci
. 2002 Jan;
17(2):183-92.
PMID: 11816791
Understanding mechanisms involved in the production of Abeta has long been the central focus of cell biologists engaged in molecular AD research. The discovery of two genes that encode homologous...
10.
Siman R, Flood D, Thinakaran G, Neumar R
J Biol Chem
. 2001 Sep;
276(48):44736-43.
PMID: 11574534
Endoplasmic reticulum (ER) stress elicits protective responses of chaperone induction and translational suppression and, when unimpeded, leads to caspase-mediated apoptosis. Alzheimer's disease-linked mutations in presenilin-1 (PS-1) reportedly impair ER stress-mediated...