G R van den Brink
Overview
Explore the profile of G R van den Brink including associated specialties, affiliations and a list of published articles.
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31
Citations
1163
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Recent Articles
1.
Smit W, de Boer R, Meijer B, Spaan C, van Roest M, Koelink P, et al.
Stem Cell Res
. 2021 Aug;
55:102499.
PMID: 34399164
Modulation of global mRNA translation, which is essential for intestinal stem cell function, is controlled by Wnt signaling. Loss of tumor supressor APC in stem cells drives adenoma formation through...
2.
Sahami S, Konte K, Buskens C, Tanis P, Lowenberg M, Ponsioen C, et al.
United European Gastroenterol J
. 2017 Jun;
5(4):554-562.
PMID: 28588887
Objective: The primary objective of this study was to assess proximal disease extension of ulcerative colitis (UC) over time, with disease behaviour pattern and risk factors for proximal disease extension...
3.
Strik A, van den Brink G, Ponsioen C, Mathot R, Lowenberg M, dHaens G
Aliment Pharmacol Ther
. 2017 Feb;
45(8):1128-1134.
PMID: 28230306
Background: Loss of response to anti-tumour necrosis factor (TNF) therapy in patients with inflammatory bowel disease (IBD) is often caused by anti-drug antibody formation with neutralisation of drug effect. Addition...
4.
Doorenspleet M, Westera L, Peters C, Hakvoort T, Esveldt R, Vogels E, et al.
J Crohns Colitis
. 2017 Feb;
11(7):831-839.
PMID: 28158397
Background And Aim: T cells are key players in the chronic intestinal inflammation that characterises Crohn's disease. Here we aim to map the intestinal T-cell receptor [TCR] repertoire in patients...
5.
Sahami S, Buskens C, van den Brink G, dHaens G, Bemelman W
Am J Gastroenterol
. 2017 Jan;
112(1):184-185.
PMID: 28050046
No abstract available.
6.
van Lidth de Jeude J, Meijer B, Wielenga M, Spaan C, Baan B, Rosekrans S, et al.
Oncogene
. 2016 Nov;
36(24):3397-3405.
PMID: 27819675
Intestinal epithelial stem cells are highly sensitive to differentiation induced by endoplasmic reticulum (ER) stress. Colorectal cancer develops from mutated intestinal epithelial stem cells. The most frequent initiating mutation occurs...
7.
Wildenberg M, Koelink P, Diederen K, Te Velde A, Wolfkamp S, Nuij V, et al.
Mucosal Immunol
. 2016 Jul;
10(2):352-360.
PMID: 27435106
Thiopurines are commonly used drugs in the therapy of Crohn's disease, but unfortunately only show a 30% response rate. The biological basis for the thiopurine response is unclear, thus hampering...
8.
Turfkruyer M, Rekima A, Macchiaverni P, Le Bourhis L, Muncan V, van den Brink G, et al.
Mucosal Immunol
. 2015 Nov;
9(2):479-91.
PMID: 26530133
Increased risk of allergy during early life indicates deficient immune regulation in this period of life. To date, the cause for inefficient neonatal immune regulation has never been elucidated. We...
9.
Sahami S, Kooij I, Meijer S, van den Brink G, Buskens C, Te Velde A
Am J Gastroenterol
. 2015 Sep;
111(2):163-9.
PMID: 26416189
The human appendix has long been considered as a vestigial organ, an organ that has lost its function during evolution. In recent years, however, reports have emerged that link the...
10.
Voorneveld P, Kodach L, Jacobs R, van Noesel C, Peppelenbosch M, Korkmaz K, et al.
Br J Cancer
. 2014 Nov;
112(1):122-30.
PMID: 25393365
Background: Constitutive Wnt activation is essential for colorectal cancer (CRC) initiation but also underlies the cancer stem cell phenotype, metastasis and chemosensitivity. Importantly Wnt activity is still modulated as evidenced...