G R van den Brink
Overview
Explore the profile of G R van den Brink including associated specialties, affiliations and a list of published articles.
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31
Citations
1163
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Recent Articles
11.
Phesse T, Myant K, Cole A, Ridgway R, Pearson H, Muncan V, et al.
Cell Death Differ
. 2014 Mar;
21(6):956-66.
PMID: 24583641
Recent studies have suggested that C-MYC may be an excellent therapeutic cancer target and a number of new agents targeting C-MYC are in preclinical development. Given most therapeutic regimes would...
12.
Heijmans J, Buller N, Hoff E, Dihal A, van der Poll T, van Zoelen M, et al.
Oncogene
. 2012 Apr;
32(9):1202-6.
PMID: 22469986
Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or...
13.
Duijvestein M, van den Brink G, Hommes D
J Crohns Colitis
. 2010 Dec;
2(2):99-106.
PMID: 21172199
Hematopoietic stem cell transplantation and mesenchymal stromal cell therapy are currently under investigation as novel therapies for inflammatory bowel diseases. Hematopoietic stem cells (HSC) are thought to repopulate the immune...
14.
Heijmans J, Buller N, Muncan V, van den Brink G
Biochim Biophys Acta
. 2010 Dec;
1822(1):9-13.
PMID: 21146606
The link between inflammation and colorectal cancer development is becoming increasingly clear. It had long been recognized that patients with inflammatory bowel disease are at an increased risk of colon...
15.
Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, et al.
J Pathol
. 2008 May;
215(4):411-20.
PMID: 18498120
Helicobacter pylori infection induces intestinal metaplasia of the stomach, a preneoplastic lesion associated with an increased risk for gastric cancer development. Intestinal metaplasia is induced by the intestine-specific transcription factor...
16.
Bos C, Kodach L, van den Brink G, Diks S, van Santen M, Richel D, et al.
Oncogene
. 2006 Aug;
25(49):6447-56.
PMID: 16878161
Nonsteroidal anti-inflammatory drugs show chemopreventive efficacy in colon cancer, but the mechanism behind this remains unclear. Elucidating this mechanism is seen as vital to the development of new chemopreventive agents....
17.
18.
Bleuming S, Kodach L, Garcia Leon M, Richel D, Peppelenbosch M, Reitsma P, et al.
J Pathol
. 2006 Mar;
209(2):190-7.
PMID: 16550632
Morphogens regulate epithelial cell fate decisions in the adult gastrointestinal tract. The authors hypothesized that influx of inflammatory cells into the lamina propria may disturb the normal expression gradients of...
19.
Bleuming S, Peppelenbosch M, Roberts D, van den Brink G
Scand J Gastroenterol
. 2004 Mar;
39(2):93-8.
PMID: 15000268
No abstract available.
20.
de Santa Barbara P, van den Brink G, Roberts D
Cell Mol Life Sci
. 2003 Aug;
60(7):1322-32.
PMID: 12943221
The gastrointestinal tract develops from a simple tube to a complex organ with patterns of differentiation along four axes of asymmetry. The organ is composed of all three germ layers...