G R Macgregor
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Explore the profile of G R Macgregor including associated specialties, affiliations and a list of published articles.
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32
Citations
3560
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Recent Articles
1.
Macgregor G, Nolan G, Fiering S, Roederer M, Herzenberg L
Methods Mol Biol
. 2011 Mar;
7:217-35.
PMID: 21416358
Our understanding of the molecular mechanisms that govern gene expression has been facilitated by the ability to introduce recombinant DNA molecules into heterologous cellular systems both in vitro and in...
2.
Macgregor G
Reproduction
. 2002 Aug;
124(3):377-86.
PMID: 12201811
Chimaeric analysis is a powerful method to address questions about the cell-autonomous nature of defects in spermatogenesis. Symplastic spermatids (sys) mice have a recessive mutation that causes male sterility due...
3.
Ross A, Amy S, Mahar P, LINDSTEN T, Knudson C, Thompson C, et al.
Dev Biol
. 2002 Jan;
239(2):295-308.
PMID: 11784036
Male mice deficient in BCLW, a death-protecting member of the BCL2 family, are sterile due to an arrest in spermatogenesis that is associated with a gradual loss of germ cells...
4.
Russell L, Warren J, Debeljuk L, Richardson L, Mahar P, Waymire K, et al.
Biol Reprod
. 2001 Jun;
65(1):318-32.
PMID: 11420255
Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice that are mutant for Bclw display progressive and nearly complete testicular degeneration. We performed a morphometric evaluation...
5.
Zong W, LINDSTEN T, Ross A, Macgregor G, Thompson C
Genes Dev
. 2001 Jun;
15(12):1481-6.
PMID: 11410528
The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce apoptosis in wild-type cells and cells from either bax(-/-) or bak(-/-) animals. In contrast, constitutively active...
6.
Wei M, Zong W, Cheng E, LINDSTEN T, Panoutsakopoulou V, Ross A, et al.
Science
. 2001 Apr;
292(5517):727-30.
PMID: 11326099
Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of a "BH3-domain-only" BCL-2 family member,...
7.
LINDSTEN T, Ross A, King A, Zong W, Rathmell J, Shiels H, et al.
Mol Cell
. 2001 Feb;
6(6):1389-99.
PMID: 11163212
Proapoptotic Bcl-2 family members have been proposed to play a central role in regulating apoptosis. However, mice lacking bax display limited phenotypic abnormalities. As presented here, bak(-/-) mice were found...
8.
Sligh J, Levy S, Waymire K, Allard P, Dillehay D, Nusinowitz S, et al.
Proc Natl Acad Sci U S A
. 2000 Dec;
97(26):14461-6.
PMID: 11106380
We report a method for introducing mtDNA mutations into the mouse female germ line by means of embryonic stem (ES) cell cybrids. Mitochondria were recovered from the brain of a...
9.
Esposito L, Kokoszka J, Waymire K, Cottrell B, Macgregor G, Wallace D
Free Radic Biol Med
. 2000 Apr;
28(5):754-66.
PMID: 10754271
Oxidative stress resulting from mitochondrially derived reactive oxygen species (ROS) has been hypothesized to damage mitochondrial oxidative phosphorylation (OXPHOS) and to be a factor in aging and degenerative disease. If...
10.
Fedde K, Blair L, Silverstein J, Coburn S, Ryan L, Weinstein R, et al.
J Bone Miner Res
. 2000 Jan;
14(12):2015-26.
PMID: 10620060
Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone...