G P Nolan
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Explore the profile of G P Nolan including associated specialties, affiliations and a list of published articles.
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83
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4797
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Recent Articles
1.
Barlow G, Schurch C, Bhate S, Phillips D, Young A, Dong S, et al.
medRxiv
. 2023 Mar;
PMID: 36993739
In autoimmune Type 1 diabetes (T1D), immune cells infiltrate and destroy the islets of Langerhans - islands of endocrine tissue dispersed throughout the pancreas. However, the contribution of cellular programs...
2.
OGorman W, Kong D, Balboni I, Rudra P, Bolen C, Ghosh D, et al.
J Autoimmun
. 2017 Apr;
PMID: 28389038
Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease with heightened disease severity in children. The incomplete understanding of the precise cellular and molecular events that drive disease activity pose...
3.
Savino A, Sarno J, Trentin L, Vieri M, Fazio G, Bardini M, et al.
Leukemia
. 2017 Mar;
31(11):2365-2375.
PMID: 28331226
Leukemias bearing CRLF2 and JAK2 gene alterations are characterized by aberrant JAK/STAT signaling and poor prognosis. The HDAC inhibitor givinostat/ITF2357 has been shown to exert anti-neoplastic activity against both systemic...
4.
Fisher D, Malkova O, Engle E, Miner C, Fulbright M, Behbehani G, et al.
Leukemia
. 2016 Dec;
31(9):1962-1974.
PMID: 28008177
Myeloproliferative neoplasms (MPNs) feature a malignant clone containing the JAK2 V617F mutation, or another mutation causing dysregulated JAK2 kinase activity. The multiple disease phenotypes of MPNs, and their tendency to...
5.
Sachs K, Itani S, Fitzgerald J, Schoeberl B, Nolan G, Tomlin C
Interface Focus
. 2014 Feb;
3(4):20130019.
PMID: 24511382
Many interesting studies aimed at elucidating the connectivity structure of biomolecular pathways make use of abundance measurements, and employ statistical and information theoretic approaches to assess connectivities. These studies often...
6.
Pear W, Scott M, Nolan G
Methods Mol Med
. 2014 Feb;
7:41-57.
PMID: 24493417
Retroviral gene transfer is presently one of the most powerful techniques for introducing stably heritable genetic material into mammalian cells (reviewed in ref. 1). One serious drawback of this technique,...
7.
Macgregor G, Nolan G, Fiering S, Roederer M, Herzenberg L
Methods Mol Biol
. 2011 Mar;
7:217-35.
PMID: 21416358
Our understanding of the molecular mechanisms that govern gene expression has been facilitated by the ability to introduce recombinant DNA molecules into heterologous cellular systems both in vitro and in...
8.
Sachs K, Itani S, Fitzgerald J, Wille L, Schoeberl B, Dahleh M, et al.
Pac Symp Biocomput
. 2009 Feb;
:63-74.
PMID: 19209696
Bayesian network structure learning is a useful tool for elucidation of regulatory structures of biomolecular pathways. The approach however is limited by its acyclicity constraint, a problematic one in the...
9.
Swift S, Lorens J, Achacoso P, Nolan G
Curr Protoc Immunol
. 2008 Apr;
Chapter 10:Unit 10.17C.
PMID: 18432682
This unit details the applications of one of the more common retroviral packaging systems, based on the highly transfectable 293T cell. The packaging system employs the use of the Phoenix...
10.
Stitz J, Krutzik P, Nolan G
Nucleic Acids Res
. 2005 Feb;
33(4):e39.
PMID: 15731332
We report a novel approach that allows for the rapid identification of proteins mediating phosphorylation in signaling cascades after specific stimulation. As a proof of concept, we used the interferon-...