G K Whitfield
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Explore the profile of G K Whitfield including associated specialties, affiliations and a list of published articles.
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34
Citations
1205
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Recent Articles
11.
Haussler M, Whitfield G, Haussler C, Hsieh J, Thompson P, Selznick S, et al.
J Bone Miner Res
. 1998 Apr;
13(3):325-49.
PMID: 9525333
No abstract available.
12.
Haussler M, Haussler C, Jurutka P, Thompson P, Hsieh J, Remus L, et al.
J Endocrinol
. 1997 Oct;
154 Suppl:S57-73.
PMID: 9379138
Vitamin D plays a major role in bone mineral homeostasis by promoting the transport of calcium and phosphate to ensure that the blood levels of these ions are sufficient for...
13.
Jurutka P, Hsieh J, Remus L, Whitfield G, Thompson P, Haussler C, et al.
J Biol Chem
. 1997 Jun;
272(23):14592-9.
PMID: 9169418
To investigate a potential ligand-dependent transcriptional activation domain (AF-2) in the C-terminal region of the human vitamin D receptor (hVDR), two conserved residues, Leu-417 and Glu-420, were replaced with alanines...
14.
Whitfield G, Selznick S, Haussler C, Hsieh J, Galligan M, Jurutka P, et al.
Mol Endocrinol
. 1996 Dec;
10(12):1617-31.
PMID: 8961271
Hereditary hypocalcemic vitamin D-resistant rickets is attributable to defects in the nuclear receptor for 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Two novel point mutations (I314S and R391C) identified in the hormone-binding domain of...
15.
Jurutka P, Hsieh J, Nakajima S, Haussler C, Whitfield G, Haussler M
Proc Natl Acad Sci U S A
. 1996 Apr;
93(8):3519-24.
PMID: 8622969
The potential functional significance of human 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (hVDR) phosphorylation at Ser-208 was evaluated by cotransfecting COS-7 kidney cells with hVDR constructs and the catalytic subunit of human...
16.
Nakajima S, Hsieh J, Jurutka P, Galligan M, Haussler C, Whitfield G, et al.
J Biol Chem
. 1996 Mar;
271(9):5143-9.
PMID: 8617794
The significance of conserved cysteines at positions 288, 337, and 369 in the hormone binding domain of the human vitamin D receptor was evaluated by individual site-directed mutagenesis to glycine....
17.
Hsieh J, Jurutka P, Selznick S, Reeder M, Haussler C, Whitfield G, et al.
Biochem Biophys Res Commun
. 1995 Oct;
215(1):1-7.
PMID: 7575575
The T-box mediates binding of retinoid X receptor (RXR) homodimers to DNA while the P- and D-box in the zinc fingers of steroid hormone receptors play roles in DNA-binding specificity...
18.
Whitfield G, Hsieh J, Nakajima S, MacDonald P, Thompson P, Jurutka P, et al.
Mol Endocrinol
. 1995 Sep;
9(9):1166-79.
PMID: 7491109
Residues located between amino acids 244 and 263 in the human vitamin D receptor (hVDR) show extensive homology with other members of the steroid/thyroid/retinoid hormone receptor superfamily. The corresponding region...
19.
Haussler M, Jurutka P, Hsieh J, Thompson P, Selznick S, Haussler C, et al.
Bone
. 1995 Aug;
17(2 Suppl):33S-38S.
PMID: 8579895
The nuclear vitamin D receptor (VDR) binds the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]hormone with high affinity and elicits its actions to regulate gene expression in target cells by binding to vitamin D-responsive...
20.
Whitfield G, Hsieh J, Jurutka P, Selznick S, Haussler C, MacDonald P, et al.
J Nutr
. 1995 Jun;
125(6 Suppl):1690S-1694S.
PMID: 7782928
Recent studies have identified a heterodimer of the vitamin D receptor (VDR) and the retinoid X receptor (RXR) as the active complex for mediating positive transcriptional effects of 1,25-dihydroxyvitamin D3...