G H Karpen
Overview
Explore the profile of G H Karpen including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
3880
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Recent Articles
1.
Maggert K, Karpen G
Genetics
. 2001 Aug;
158(4):1615-28.
PMID: 11514450
The centromere is essential for proper segregation and inheritance of genetic information. Centromeres are generally regulated to occur exactly once per chromosome; failure to do so leads to chromosome loss...
2.
Sullivan B, Blower M, Karpen G
Nat Rev Genet
. 2001 Aug;
2(8):584-96.
PMID: 11483983
The centromere is the genetic locus required for chromosome segregation. It is the site of spindle attachment to the chromosomes and is crucial for the transfer of genetic information between...
3.
Blower M, Karpen G
Nat Cell Biol
. 2001 Aug;
3(8):730-9.
PMID: 11483958
Centromere function requires the coordination of many processes including kinetochore assembly, sister chromatid cohesion, spindle attachment and chromosome movement. Here we show that CID, the Drosophila homologue of the CENP-A...
4.
Hari K, Cook K, Karpen G
Genes Dev
. 2001 Jun;
15(11):1334-48.
PMID: 11390354
The conserved heterochromatic location of centromeres in higher eukaryotes suggests that intrinsic properties of heterochromatin are important for chromosome inheritance. Based on this hypothesis, mutations in Drosophila melanogaster that alter...
5.
Dobie K, Kennedy C, Velasco V, McGrath T, Weko J, Patterson R, et al.
Genetics
. 2001 Apr;
157(4):1623-37.
PMID: 11290718
Faithful chromosome inheritance is a fundamental biological activity and errors contribute to birth defects and cancer progression. We have performed a P-element screen in Drosophila melanogaster with the aim of...
6.
Lopez J, Karpen G
Curr Biol
. 2000 Sep;
10(16):997-1000.
PMID: 10985388
Attachment, or cohesion, between sister chromatids is essential for their proper segregation in mitosis and meiosis [1,2]. Sister chromatids are tightly apposed at their centromeric regions, but it is not...
7.
8.
Adams M, Celniker S, Holt R, Evans C, Gocayne J, Amanatides P, et al.
Science
. 2000 Mar;
287(5461):2185-95.
PMID: 10731132
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common...
9.
Dobie K, Hari K, Maggert K, Karpen G
Curr Opin Genet Dev
. 1999 May;
9(2):206-17.
PMID: 10322137
Centromeres and the associated kinetochores are involved in essential aspects of chromosome transmission. Recent advances have included the identification and understanding of proteins that have a pivotal role in centromere...
10.