G H Karpen
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Explore the profile of G H Karpen including associated specialties, affiliations and a list of published articles.
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31
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3880
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Recent Articles
11.
Karpen G, Allshire R
Trends Genet
. 1998 Jan;
13(12):489-96.
PMID: 9433139
The centromere is required to ensure the equal distribution of replicated chromosomes to daughter nuclei. Centromeres are frequently associated with heterochromatin, an enigmatic nuclear component that causes the epigenetic transcriptional...
12.
Williams B, Murphy T, Goldberg M, Karpen G
Nat Genet
. 1998 Jan;
18(1):30-7.
PMID: 9425896
Chromosome fragments that lack centromeric DNA (structurally acentric chromosomes) are usually not inherited in mitosis and meiosis. We previously described the isolation, after irradiation of a Drosophila melanogaster mini-chromosome, of...
13.
Cook K, Murphy T, Nguyen T, Karpen G
Genetics
. 1997 Mar;
145(3):737-47.
PMID: 9055083
Deletions in the Drosophila minichromosome Dp1187 were used to investigate the genetic interactions of trans-acting genes with the centromere. Mutations in several genes known to have a role in chromosome...
14.
Donaldson K, Karpen G
Genetics
. 1997 Feb;
145(2):325-37.
PMID: 9071587
Position effect variegation (PEV) is the clonal inactivation of euchromatic or heterochromatic genes that are abnormally positioned within a chromosome. PEV can be influenced by modifiers in trans, including single...
15.
Karpen G, Le M, Le H
Science
. 1996 Jul;
273(5271):118-22.
PMID: 8658180
The chromosomal requirements for achiasmate (nonexchange) homolog disjunction in Drosophila female meiosis I have been identified with the use of a series of molecularly defined minichromosome deletion derivatives. Efficient disjunction...
16.
Le M, Duricka D, Karpen G
Genetics
. 1995 Sep;
141(1):283-303.
PMID: 8536977
Heterochromatin is a ubiquitous yet poorly understood component of multicellular eukaryotic genomes. Major gaps exist in our knowledge of the nature and overall organization of DNA sequences present in heterochromatin....
17.
Murphy T, Karpen G
Cell
. 1995 Aug;
82(4):599-609.
PMID: 7664339
The DNA elements responsible for centromere activity in a metazoan have been localized using the Drosophila minichromosome Dp1187. Deleted minichromosomes were generated by irradiation mutagenesis, and their molecular structures were...
18.
Murphy T, Karpen G
Cell
. 1995 Apr;
81(1):139-48.
PMID: 7720069
In this study, we demonstrate a role for extracentromeric sequences in chromosome inheritance. Genetic analyses indicate that transmission of the Drosophila minichromosome Dp1187 is sensitive to the dosage of nod+,...
19.
Karpen G, Spradling A
Proc Natl Acad Sci U S A
. 1994 Sep;
91(19):9042-6.
PMID: 8090766
Recombination and conversion have been proposed to drive the concerted evolution of tandemly repeated DNA sequences. However, specific correction events within the repeated genes of multicellular organisms have not been...
20.
Cook K, Karpen G
Proc Natl Acad Sci U S A
. 1994 Jun;
91(12):5219-21.
PMID: 8031404
The demonstration by Zhang and Spradling (1) of efficient P element transposition into heterochromatic regions will aid ongoing studies of heterochromatin structure and function. P element insertions will provide entry...