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G Eggertsen

Explore the profile of G Eggertsen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 76
Citations 920
Followers 0
Related Specialties
Biochemistry
General Medicine
Allergy & Immunology
Top 10 Co-Authors
I Bjorkhem
M Gafvels
B Angelin
U Hellman
J Sjoquist
A Lundwall
U Andersson
L Berglund
M Eriksson
M Olin
Published In
J Intern Med
J Lipid Res
J Biol Chem
Biochim Biophys Acta
Eur J Biochem
Affiliations
Soon will be listed here.
Recent Articles
1.
Unique case of cerebrotendinous xanthomatosis revisited: All the mutations responsible for this disease are present in the CYP27A1 gene
Jiao H, Olin M, Hansson M, Eggertsen G, Eriksson M, Angelin B, et al.
J Intern Med . 2017 Nov; 283(6):604-606. PMID: 29095540
No abstract available.
2.
The thyroid receptor β modulator GC-1 reduces atherosclerosis in ApoE deficient mice
Kannisto K, Rehnmark S, Slatis K, Webb P, Larsson L, Gafvels M, et al.
Atherosclerosis . 2014 Dec; 237(2):544-54. PMID: 25463087
Thyroid hormone reduces plasma cholesterol and increases expression of low-density lipoprotein receptor (LDL-R) in liver, an effect mediated by thyroid receptor β (TRβ). The selective TRβ modulator GC-1 also enhances...
3.
Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism
Hu X, Bonde Y, Eggertsen G, Rudling M
J Intern Med . 2013 Oct; 275(1):27-38. PMID: 24118394
Objective: Bile acid (BA) synthesis is regulated by negative feedback end-product inhibition, initiated by farnesoid X receptors (FXRs) in liver and gut. Studies on cholic acid (CA)-free Cyp8b1(-/-) mice have...
4.
LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile
Hu X, Steffensen K, Jiang Z, Parini P, Gustafsson J, Gafvels M, et al.
J Intern Med . 2012 Feb; 272(5):452-64. PMID: 22329358
Objectives: Liver X receptors (LXRs) are essential for the regulation of intestinal cholesterol absorption. Because two isoforms exist, LXRα and LXRβ, with overlapping but not identical functions, we investigated whether...
5.
Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase
Hansson M, Olin M, Floren C, von Bahr S, vant Hooft F, Meaney S, et al.
J Intern Med . 2007 Apr; 261(5):504-10. PMID: 17444890
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder believed to be exclusively caused by mutations in the CYP27A1 gene coding for the enzyme sterol 27-hydroxylase. Common findings in CTX...
6.
Polymorphism in the coding part of the sterol 12alpha-hydroxylase gene does not explain the marked differences in the ratio of cholic acid and chenodeoxycholic acid in human bile
Abrahamsson A, Gafvels M, Reihner E, Bjorkhem I, Einarsson C, Eggertsen G
Scand J Clin Lab Invest . 2005 Nov; 65(7):595-600. PMID: 16271991
Objective: In humans, two primary bile acids are synthesized: cholic acid (CA) and chenodeoxycholic acid (CDCA), the first and rate-limiting enzyme being cholesterol 7alpha-hydroxylase (CYP7A1). CA has one more hydroxyl...
7.
Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice
Wang J, Einarsson C, Murphy C, Parini P, Bjorkhem I, Gafvels M, et al.
J Lipid Res . 2005 Nov; 47(2):421-30. PMID: 16264196
As previously reported by us, mice with targeted disruption of the CYP8B1 gene (CYP8B1-/-) fail to produce cholic acid (CA), upregulate their bile acid synthesis, reduce the absorption of dietary...
8.
Autosomal recessive hypercholesterolaemia: normalization of plasma LDL cholesterol by ezetimibe in combination with statin treatment
Lind S, Olsson A, Eriksson M, Rudling M, Eggertsen G, Angelin B
J Intern Med . 2004 Oct; 256(5):406-12. PMID: 15485476
Background: Severe hereditary hypercholesterolaemia is most frequently due to familial hypercholesterolaemia (FH), caused by mutations in the LDL receptor (LDLR) gene. However, a phenotype very similar to FH may also...
9.
Enrichment of HFE mutations in Swedish patients with familial and sporadic form of porphyria cutanea tarda
Harper P, Floderus Y, Holmstrom P, Eggertsen G, Gafvels M
J Intern Med . 2004 May; 255(6):684-8. PMID: 15147533
No abstract available.
10.
Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls
Holmstrom P, MARMUR J, Eggertsen G, Gafvels M, Stal P
Gut . 2002 Oct; 51(5):723-30. PMID: 12377814
Background And Aims: The role of the HFE S65C mutation in the development of hepatic iron overload is unknown. The aim of the present study was: (A) to determine the...