G E Begg
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Explore the profile of G E Begg including associated specialties, affiliations and a list of published articles.
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10
Citations
326
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Recent Articles
1.
Begg G, Speicher D
J Biomol Tech
. 2009 Jun;
10(1):17-20.
PMID: 19499002
Recombinant proteins with highly reactive thiol groups can form disulfide adducts with reducing agents commonly used in protein purification, such as beta-mercaptoethanol and dithiothreitol. These adducts can interfere with protein-protein...
2.
Begg G, Harper S, Speicher D
Curr Protoc Protein Sci
. 2008 Apr;
Chapter 7:Unit 7.10.
PMID: 18429196
Recombinant proteins are subject to many forms of heterogeneity, including aggregation, proteolytic degradation, chemical modification, mutation, and incorrect translation. This unit describes methods for the detection and identification of these...
3.
Harper S, Begg G, Speicher D
Biochemistry
. 2001 Aug;
40(33):9935-43.
PMID: 11502188
Human erythrocyte spectrin is an antiparallel heterodimer comprised of a 280 kDa alpha subunit and a 246 kDa beta subunit which further associates into tetramers in the red cell membrane...
4.
Trebak M, Begg G, Chong J, Kanazireva E, Herlyn D, Speicher D
J Biol Chem
. 2000 Nov;
276(3):2299-309.
PMID: 11058587
The GA733-2 antigen (GA733) is a homotypic calcium-independent cell adhesion molecule (CAM) present in most normal human epithelial cells and gastrointestinal carcinomas. Because oligomerization of some CAMs regulates cell adhesion...
5.
Lechner M, Begg G, Speicher D, Rauscher 3rd F
Mol Cell Biol
. 2000 Aug;
20(17):6449-65.
PMID: 10938122
The KRAB domain is a highly conserved transcription repression module commonly found in eukaryotic zinc finger proteins. KRAB-mediated repression requires binding to the KAP-1 corepressor, which in turn recruits members...
6.
Peng H, Begg G, Harper S, Friedman J, Speicher D, Rauscher 3rd F
J Biol Chem
. 2000 Apr;
275(24):18000-10.
PMID: 10748030
The Kruppel-associated box (KRAB) domain is a 75-amino acid transcriptional repressor module commonly found in eukaryotic zinc finger proteins. KRAB-mediated gene silencing requires binding to the RING-B box-coiled-coil domain of...
7.
Peng H, Begg G, Schultz D, Friedman J, Jensen D, Speicher D, et al.
J Mol Biol
. 2000 Feb;
295(5):1139-62.
PMID: 10653693
The KRAB domain is a 75 amino acid residue transcriptional repression module commonly found in eukaryotic zinc-finger proteins. KRAB-mediated gene silencing requires binding to the corepressor KAP-1. The KRAB:KAP-1 interaction...
8.
Begg G, Harper S, Morris M, Speicher D
J Biol Chem
. 2000 Feb;
275(5):3279-87.
PMID: 10652315
The spectrin heterodimer is formed by the antiparallel lateral association of an alpha and a beta subunit, each of which comprises largely a series of homologous triple-helical motifs. Initiation of...
9.
Begg G, Morris M, RALSTON G
Biochemistry
. 1997 Jun;
36(23):6977-85.
PMID: 9188694
The self-association of ovine brain spectrin in 0.1-1.5 M NaCl (pH 7.5) was studied using sedimentation velocity and sedimentation equilibrium techniques. Brain spectrin is tetrameric at sedimentation equilibrium at a...
10.
Begg G, RALSTON G, Morris M
Biophys Chem
. 1994 Sep;
52(1):63-73.
PMID: 7948712
The effect of added NaCl (0-150 mM) and temperature (6-65 degrees C) on the conformation of erythrocyte spectrin was investigated using 400 MHz 1H NMR. The relatively narrow resonances (20-40...