G D Chazenbalk
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Explore the profile of G D Chazenbalk including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Chazenbalk G, Pichurin P, Guo J, Rapoport B, McLachlan S
Clin Exp Immunol
. 2005 Jan;
139(2):216-24.
PMID: 15654820
Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR)...
2.
Chazenbalk G, McLachlan S, Ochi Y, Nagayama Y, Rapoport B
Thyroid
. 2002 Mar;
12(2):115-20.
PMID: 11916280
Recently, many exceptions have been reported that undermine the concept that the epitopes for thyroid-stimulating autoantibodies (TSAb) and thyrotropin-blocking autoantibodies (TBAb) lie within the N-terminal and C-terminal portions of the...
3.
Pichurin P, Yan X, Farilla L, Guo J, Chazenbalk G, Rapoport B, et al.
Endocrinology
. 2001 Jul;
142(8):3530-6.
PMID: 11459799
Two approaches have been developed to induce TSH receptor antibodies in mice with properties resembling those in Graves' disease, the Shimojo model of injecting live fibroblasts coexpressing the TSH receptor...
4.
Chazenbalk G, McLachlan S, Chen C, Rapoport B
Eur J Biochem
. 2001 Apr;
268(8):2261-9.
PMID: 11298743
To gain insight into the thyrotropin hormone (TSH) receptor (TSHR) cleavage, we sought to convert the noncleaving luteinizing hormone (LH) receptor (LHR) into a cleaved, two-subunit molecule. For this purpose,...
5.
Tanaka K, Chazenbalk G, Rapoport B, McLachlan S
Thyroid
. 2001 Apr;
11(2):111-4.
PMID: 11288979
Cleavage of thyrotropin receptors (TSHR) on the cell surface into disulfide-linked A and B subunits involves deletion of an intervening region that corresponds approximately to a 50 amino acid "insertion"...
6.
Chen C, Tanaka K, Chazenbalk G, McLachlan S, Rapoport B
J Biol Chem
. 2001 Mar;
276(18):14767-72.
PMID: 11278376
We observed amino acid homology between the cysteine-rich N terminus of the thyrotropin receptor (TSHR) ectodomain and epidermal growth factor-like repeats in the laminin gamma1 chain. Thyroid-stimulating autoantibodies (TSAb), the...
7.
Chazenbalk G, McLachlan S, Pichurin P, Yan X, Rapoport B
J Clin Endocrinol Metab
. 2001 Mar;
86(3):1287-93.
PMID: 11238522
A secreted recombinant TSH receptor (TSHR) ectodomain variant (TSHR-289) neutralizes TSHR autoantibodies in Graves' disease, but is heterogeneous in containing both immunologically active and inactive molecules and is also unstable....
8.
Tanaka K, Chazenbalk G, McLachlan S, Rapoport B
Endocrinology
. 2000 Oct;
141(10):3573-7.
PMID: 11014210
Some TSH receptors (TSHR) on the cell surface cleave into A and B subunits. Cleavage at upstream Site 1 is followed by the proteolytic excision of an intervening C peptide...
9.
Chazenbalk G, Pichurin P, McLachlan S, Rapoport B
Thyroid
. 1999 Dec;
9(11):1057-61.
PMID: 10595452
There is, at present, no assay in clinical use for the direct assay of autoantibody binding to the thyrotropin receptor (TSHR). We now describe a direct thyrotropin receptor autoantibody binding...
10.
Tanaka K, Chazenbalk G, McLachlan S, Rapoport B
J Biol Chem
. 1999 Nov;
274(48):33979-84.
PMID: 10567361
We studied cell surface thyrotropin receptor (TSHR) by biotinylating proteins on the surface of metabolically labeled, intact cells. In addition to TSHR cleaved into A and B subunits, mature single-chain...