G Brett Robb
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Explore the profile of G Brett Robb including associated specialties, affiliations and a list of published articles.
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29
Citations
1887
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Recent Articles
1.
Fluke K, Dai N, Wolf E, Fuchs R, Ho P, Talbott V, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(45):e2405999121.
PMID: 39471227
Ribosome structure and activity are challenged at high temperatures, often demanding modifications to ribosomal RNAs (rRNAs) to retain translation fidelity. LC-MS/MS, bisulfite-sequencing, and high-resolution cryo-EM structures of the archaeal ribosome...
2.
Fluke K, Fuchs R, Tsai Y, Talbott V, Elkins L, Febvre H, et al.
Nat Commun
. 2024 Aug;
15(1):7272.
PMID: 39179532
RNAs are often modified to invoke new activities. While many modifications are limited in frequency, restricted to non-coding RNAs, or present only in select organisms, 5-methylcytidine (mC) is abundant across...
3.
Chan S, Mole C, Nye D, Mitchell L, Dai N, Buss J, et al.
RNA
. 2023 Aug;
29(11):1803-1817.
PMID: 37625853
The mammalian mRNA 5' cap structures play important roles in cellular processes such as nuclear export, efficient translation, and evading cellular innate immune surveillance and regulating 5'-mediated mRNA turnover. Hence,...
4.
Urbaitis T, Gasiunas G, Young J, Hou Z, Paulraj S, Godliauskaite E, et al.
EMBO Rep
. 2022 Oct;
23(12):e55481.
PMID: 36268581
Most CRISPR-type V nucleases are stimulated to cleave double-stranded (ds) DNA targets by a T-rich PAM, which restricts their targeting range. Here, we identify and characterize a new family of...
5.
Christie K, Guo J, Silverstein R, Doll R, Mabuchi M, Stutzman H, et al.
Nat Biotechnol
. 2022 Oct;
41(3):409-416.
PMID: 36203014
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific motifs, whereas wild-type...
6.
Chan S, Whipple J, Dai N, Kelley T, Withers K, Tzertzinis G, et al.
RNA
. 2022 Jun;
28(8):1144-1155.
PMID: 35680168
Advances in mRNA synthesis and lipid nanoparticles technologies have helped make mRNA therapeutics and vaccines a reality. The 5' cap structure is a crucial modification required to functionalize synthetic mRNA...
7.
Fuchs R, Curcuru J, Mabuchi M, Noireterre A, Weigele P, Sun Z, et al.
Commun Biol
. 2022 Apr;
5(1):325.
PMID: 35388146
CRISPR-Cas12a proteins are RNA-guided endonucleases that cleave invading DNA containing target sequences adjacent to protospacer adjacent motifs (PAM). Cas12a orthologs have been repurposed for genome editing in non-native organisms by...
8.
Mendez-Mancilla A, Wessels H, Legut M, Kadina A, Mabuchi M, Walker J, et al.
Cell Chem Biol
. 2021 Aug;
29(2):321-327.e4.
PMID: 34343484
RNA-targeting CRISPR-Cas13 proteins have recently emerged as a powerful platform to modulate gene expression outcomes. However, protein and CRISPR RNA (crRNA) delivery in human cells can be challenging with rapid...
9.
Mohanraju P, Mougiakos I, Albers J, Mabuchi M, Fuchs R, Curcuru J, et al.
CRISPR J
. 2021 Feb;
4(1):82-91.
PMID: 33538626
The ability of CRISPR-Cas12a nucleases to function reliably in a wide range of species has been key to their rapid adoption as genome engineering tools. However, so far, Cas12a nucleases...
10.
Gasiunas G, Young J, Karvelis T, Kazlauskas D, Urbaitis T, Jasnauskaite M, et al.
Nat Commun
. 2020 Nov;
11(1):5512.
PMID: 33139742
Bacterial Cas9 nucleases from type II CRISPR-Cas antiviral defence systems have been repurposed as genome editing tools. Although these proteins are found in many microbes, only a handful of variants...