G Auerbach
Overview
Explore the profile of G Auerbach including associated specialties, affiliations and a list of published articles.
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18
Citations
565
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Recent Articles
1.
Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, et al.
J Mol Biol
. 2001 Oct;
312(5):1051-7.
PMID: 11580249
Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in mammals through feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by a regulatory...
2.
Auerbach G, Herrmann A, Bracher A, Bader G, Gutlich M, Fischer M, et al.
Proc Natl Acad Sci U S A
. 2000 Nov;
97(25):13567-72.
PMID: 11087827
The crystal structure of recombinant human GTP cyclohydrolase I was solved by Patterson search methods by using the coordinates of the Escherichia coli enzyme as a model. The human as...
3.
Dams T, Auerbach G, Bader G, Jacob U, Ploom T, Huber R, et al.
J Mol Biol
. 2000 Mar;
297(3):659-72.
PMID: 10731419
Two high-resolution structures have been obtained for dihydrofolate reductase from the hyperthermophilic bacterium Thermotoga maritima in its unliganded state, and in its ternary complex with the cofactor NADPH and the...
4.
Thony B, Auerbach G, Blau N
Biochem J
. 2000 Mar;
347 Pt 1:1-16.
PMID: 10727395
Tetrahydrobiopterin (BH(4)) cofactor is essential for various processes, and is present in probably every cell or tissue of higher organisms. BH(4) is required for various enzyme activities, and for less...
5.
Bracher A, Fischer M, Eisenreich W, Ritz H, Schramek N, Boyle P, et al.
J Biol Chem
. 1999 Jun;
274(24):16727-35.
PMID: 10358012
GTP cyclohydrolase I catalyzes the conversion of GTP to dihydroneopterin triphosphate. The replacement of histidine 179 by other amino acids affords mutant enzymes that do not catalyze the formation of...
6.
Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
Ploom T, Thony B, Yim J, Lee S, Nar H, Leimbacher W, et al.
J Mol Biol
. 1999 Feb;
286(3):851-60.
PMID: 10024455
The enzyme 6-pyruvoyl tetrahydropterin synthase (PTPS) catalyses the second step in the de novo biosynthesis of tetrahydrobiopterin, the conversion of dihydroneopterin triphosphate to 6-pyruvoyl tetrahydropterin. The Zn and Mg-dependent reaction...
7.
Auerbach G, Ostendorp R, Prade L, Korndorfer I, Dams T, Huber R, et al.
Structure
. 1998 Jul;
6(6):769-81.
PMID: 9655830
Background: L(+)-Lactate dehydrogenase (LDH) catalyzes the last step in anaerobic glycolysis, the conversion of pyruvate to lactate, with the concomitant oxidation of NADH. Extensive physicochemical and structural investigations of LDHs...
8.
Dams T, Bohm G, Auerbach G, Bader G, Schurig H, Jaenicke R
Biol Chem
. 1998 May;
379(3):367-71.
PMID: 9563834
Dihydrofolate reductase (DHFR) from the hyperthermophilic bacterium Thermotoga maritima was cloned and expressed in Escherichia coli. Sequence determination of the reported dyrA gene was repeated, and a corrected version deposited...
9.
Auerbach G, Huber R, Grattinger M, Zaiss K, Schurig H, Jaenicke R, et al.
Structure
. 1998 Mar;
5(11):1475-83.
PMID: 9384563
Background: Phosphoglycerate kinase (PGK) is essential in most living cells both for ATP generation in the glycolytic pathway of aerobes and for fermentation in anaerobes. In addition, in many plants...
10.
Auerbach G, Herrmann A, Gutlich M, Fischer M, Jacob U, Bacher A, et al.
EMBO J
. 1998 Feb;
16(24):7219-30.
PMID: 9405351
Sepiapterin reductase catalyses the last steps in the biosynthesis of tetrahydrobiopterin, the essential co-factor of aromatic amino acid hydroxylases and nitric oxide synthases. We have determined the crystal structure of...