Fukun W Hoffmann
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Explore the profile of Fukun W Hoffmann including associated specialties, affiliations and a list of published articles.
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31
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789
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Recent Articles
1.
Marcantonio E, Burger A, Chang K, Hoffmann F, Fu Y, Khadka V, et al.
Infect Immun
. 2025 Feb;
93(3):e0057824.
PMID: 39903447
Tuberculosis (TB) is notoriously difficult to treat, likely due to the complex host-pathogen interactions driven by pathogen heterogeneity. An understudied area of TB pathogenesis is host responses to bacteria (Mtb)...
2.
Green K, Ma C, Hoffmann F, Hoffmann P, Green W
Virology
. 2024 Sep;
600:110247.
PMID: 39307098
We have shown the induction of CD11bLy6C monocytic myeloid-derived suppressor cells (M-MDSCs) during infection of B6 mice by LP-BM5 immunodeficiency-inducing retrovirus. We published that the molecular mechanisms of these M-MDSCs...
3.
Nunes L, Ma C, Hoffmann F, Shay A, Pitts M, Hoffmann P
J Biol Chem
. 2024 Apr;
300(5):107259.
PMID: 38582453
Selenoprotein I (SELENOI) catalyzes the final reaction of the CDP-ethanolamine branch of the Kennedy pathway, generating the phospholipids phosphatidylethanolamine (PE) and plasmenyl-PE. Plasmenyl-PE is a key component of myelin and...
4.
Ma C, Hoffmann F, Shay A, Koo I, Green K, Green W, et al.
J Leukoc Biol
. 2024 Jan;
116(1):6-17.
PMID: 38289835
The mechanisms driving metabolic reprogramming during B cell activation are unclear, particularly roles for enzymatic pathways involved in lipid remodeling. We found that murine B cell activation with lipopolysaccharide (LPS)...
5.
Ma C, Hoffmann F, Nunes L, Urena F, Andrukhiv A, Gerschenson M, et al.
J Leukoc Biol
. 2022 Aug;
112(6):1387-1397.
PMID: 35916034
Selenoprotein I (SELENOI) is an ethanolamine phospholipid transferase contributing to cellular metabolism and the synthesis of glycosylphosphatidylinositol (GPI) anchors. SELENOI knockout (KO) in T cells has been shown to impair...
6.
Urena F, Ma C, Hoffmann F, Nunes L, Urschitz J, Moisyadi S, et al.
J Biol Chem
. 2022 Jan;
298(3):101634.
PMID: 35085550
While miRs have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T-cell activation are less clear. In initial studies, we found reduced levels...
7.
Ma C, Hoffmann F, Marciel M, Page K, Williams-Aduja M, Akana E, et al.
Mol Metab
. 2021 Jan;
47:101170.
PMID: 33484950
Objective: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts...
8.
Avery J, Yamazaki Y, Hoffmann F, Folgelgren B, Hoffmann P
Arch Biochem Biophys
. 2020 Jun;
689:108444.
PMID: 32502470
Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of phosphatidylethanolamine. Since the role of SELENOI in murine embryogenesis has...
9.
Hoffmann P, Hoffmann F, Premeaux T, Fujita T, Soprana E, Panigada M, et al.
Front Oncol
. 2019 Aug;
9:720.
PMID: 31428586
Malignant Mesothelioma (MM) is a rare and highly aggressive cancer that develops from mesothelial cells lining the pleura and other internal cavities, and is often associated with asbestos exposure. To...
10.
Bertino P, Premeaux T, Fujita T, Haun B, Marciel M, Hoffmann F, et al.
Oncoimmunology
. 2019 Aug;
8(8):1601482.
PMID: 31413910
Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells...