Frits Mattijssen
Overview
Explore the profile of Frits Mattijssen including associated specialties, affiliations and a list of published articles.
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18
Citations
792
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Recent Articles
1.
Garcia M, Meissburger B, Chan J, de Guia R, Mattijssen F, Roessler S, et al.
Adv Sci (Weinh)
. 2022 Aug;
9(29):e2104291.
PMID: 36031387
Aberrant energy metabolism and cell cycle regulation both critically contribute to malignant cell growth and both processes represent targets for anticancer therapy. It is shown here that depletion of the...
2.
Giroud M, Tsokanos F, Caratti G, Kotschi S, Khani S, Jouffe C, et al.
Diabetologia
. 2021 May;
64(8):1850-1865.
PMID: 34014371
Aims/hypothesis: Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance and systemic metabolic disturbances, adipogenesis, the formation of new adipocytes and healthy adipose...
3.
van Dierendonck X, de la Rosa Rodriguez M, Georgiadi A, Mattijssen F, Dijk W, van Weeghel M, et al.
Cell Rep
. 2020 Feb;
30(6):1811-1822.e6.
PMID: 32049012
Obesity leads to a state of chronic, low-grade inflammation that features the accumulation of lipid-laden macrophages in adipose tissue. Here, we determined the role of macrophage lipid-droplet accumulation in the...
4.
Glantschnig C, Mattijssen F, Vogl E, Ali Khan A, Garcia M, Fischer K, et al.
EMBO Rep
. 2019 Sep;
20(11):e48552.
PMID: 31559673
Aberrant activity of the glucocorticoid (GC)/glucocorticoid receptor (GR) endocrine system has been linked to obesity-related metabolic dysfunction. Traditionally, the GC/GR axis has been believed to play a crucial role in...
5.
Garcia M, Steinbauer B, Srivastava K, Singhal M, Mattijssen F, Maida A, et al.
Cell Metab
. 2017 Oct;
26(6):842-855.e5.
PMID: 29056512
Breast tumor recurrence and metastasis represent the main causes of cancer-related death in women, and treatments are still lacking. Here, we define the lipogenic enzyme acetyl-CoA carboxylase (ACC) 1 as...
6.
Niopek K, Ekim Ustunel B, Seitz S, Sakurai M, Zota A, Mattijssen F, et al.
Cell Rep
. 2017 Aug;
20(6):1422-1434.
PMID: 28793265
Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration...
7.
Dijk W, Mattijssen F, De la Rosa Rodriguez M, Valdes A, Loft A, Mandrup S, et al.
Endocrinology
. 2017 Mar;
158(5):1231-1251.
PMID: 28323980
Triglycerides are stored in specialized organelles called lipid droplets. Numerous proteins have been shown to be physically associated with lipid droplets and govern their function. Previously, the protein hypoxia-inducible lipid...
8.
Sha H, Sun S, Francisco A, Ehrhardt N, Xue Z, Liu L, et al.
Cell Metab
. 2014 Jul;
20(3):458-70.
PMID: 25066055
Sel1L is an essential adaptor protein for the E3 ligase Hrd1 in the endoplasmic reticulum (ER)-associated degradation (ERAD), a universal quality-control system in the cell; but its physiological role remains...
9.
Mattijssen F, Georgiadi A, Andasarie T, Szalowska E, Zota A, Krones-Herzig A, et al.
J Biol Chem
. 2014 May;
289(28):19279-93.
PMID: 24876382
Peroxisome proliferator-activated receptors (PPARs) play major roles in the regulation of hepatic lipid metabolism through the control of numerous genes involved in processes such as lipid uptake and fatty acid...
10.
Mattijssen F, Alex S, Swarts H, Groen A, van Schothorst E, Kersten S
Mol Metab
. 2014 Mar;
3(2):135-44.
PMID: 24634819
Dietary triglycerides are hydrolyzed in the small intestine principally by pancreatic lipase. Following uptake by enterocytes and secretion as chylomicrons, dietary lipids are cleared from the bloodstream via lipoprotein lipase....